Polymicrobial bloodstream infections per se do not increase mortality compared to monomicrobial bloodstream infections in sepsis patients : a Korean nationwide sepsis cohort study
© 2024. The Author(s)..
BACKGROUND: There is limited information about the outcomes of polymicrobial bloodstream infections in patients with sepsis. We aimed to investigate outcomes of polymicrobial bloodstream infections compared to monomicrobial bloodstream infections.
METHODS: This study used data from the Korean Sepsis Alliance Registry, a nationwide database of prospective observational sepsis cohort. Adult sepsis patients with bloodstream infections from September 2019 to December 2021 at 20 tertiary or university-affiliated hospitals in South Korea were analyzed.
RESULTS: Among the 3,823 patients with bloodstream infections, 429 of them (11.2%) had polymicrobial bloodstream infections. The crude hospital mortality of patients with sepsis with polymicrobial bloodstream infection and monomicrobial bloodstream infection was 35.7% and 30.1%, respectively (p = 0.021). However, polymicrobial bloodstream infections were not associated with hospital mortality in the proportional hazard analysis (HR 1.15 [0.97-1.36], p = 0.11). The inappropriate use of antibiotics was associated with increased mortality (HR 1.37 [1.19-1.57], p < 0.001), and source control was associated with decreased mortality (HR 0.51 [0.42-0.62], p < 0.001).
CONCLUSIONS: Polymicrobial bloodstream infections per se were not associated with hospital mortality in patients with sepsis as compared to monomicrobial bloodstream infections. The appropriate use of antibiotics and source control were associated with decreased mortality in bloodstream infections regardless of the number of microbial pathogens.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
BMC infectious diseases - 24(2024), 1 vom: 05. März, Seite 285 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Su Yeon [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 07.03.2024 Date Revised 15.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12879-024-09130-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369336216 |
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| 100 | 1 | |a Lee, Su Yeon |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Polymicrobial bloodstream infections per se do not increase mortality compared to monomicrobial bloodstream infections in sepsis patients |b a Korean nationwide sepsis cohort study |
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| 500 | |a Date Revised 15.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a BACKGROUND: There is limited information about the outcomes of polymicrobial bloodstream infections in patients with sepsis. We aimed to investigate outcomes of polymicrobial bloodstream infections compared to monomicrobial bloodstream infections | ||
| 520 | |a METHODS: This study used data from the Korean Sepsis Alliance Registry, a nationwide database of prospective observational sepsis cohort. Adult sepsis patients with bloodstream infections from September 2019 to December 2021 at 20 tertiary or university-affiliated hospitals in South Korea were analyzed | ||
| 520 | |a RESULTS: Among the 3,823 patients with bloodstream infections, 429 of them (11.2%) had polymicrobial bloodstream infections. The crude hospital mortality of patients with sepsis with polymicrobial bloodstream infection and monomicrobial bloodstream infection was 35.7% and 30.1%, respectively (p = 0.021). However, polymicrobial bloodstream infections were not associated with hospital mortality in the proportional hazard analysis (HR 1.15 [0.97-1.36], p = 0.11). The inappropriate use of antibiotics was associated with increased mortality (HR 1.37 [1.19-1.57], p < 0.001), and source control was associated with decreased mortality (HR 0.51 [0.42-0.62], p < 0.001) | ||
| 520 | |a CONCLUSIONS: Polymicrobial bloodstream infections per se were not associated with hospital mortality in patients with sepsis as compared to monomicrobial bloodstream infections. The appropriate use of antibiotics and source control were associated with decreased mortality in bloodstream infections regardless of the number of microbial pathogens | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bacteremia | |
| 650 | 4 | |a Coinfection | |
| 650 | 4 | |a Fungemia | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Sepsis | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 700 | 1 | |a Park, Mi Hyeon |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Dong Kyu |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Chae-Man |e verfasserin |4 aut | |
| 700 | 0 | |a Korean Sepsis Alliance (KSA) investigators |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Sang-Bum |e investigator |4 oth | |
| 700 | 1 | |a Suh, Gee Young |e investigator |4 oth | |
| 700 | 1 | |a Jeon, Kyeongman |e investigator |4 oth | |
| 700 | 1 | |a Ko, Ryoung-Eun |e investigator |4 oth | |
| 700 | 1 | |a Cho, Young-Jae |e investigator |4 oth | |
| 700 | 1 | |a Lee, Yeon Joo |e investigator |4 oth | |
| 700 | 1 | |a Lim, Sung Yoon |e investigator |4 oth | |
| 700 | 1 | |a Park, Sunghoon |e investigator |4 oth | |
| 700 | 1 | |a Heo, Jeongwon |e investigator |4 oth | |
| 700 | 1 | |a Lee, Jae-Myeong |e investigator |4 oth | |
| 700 | 1 | |a Kim, Kyung Chan |e investigator |4 oth | |
| 700 | 1 | |a Chang, Youjin |e investigator |4 oth | |
| 700 | 1 | |a Lee, Sang-Min |e investigator |4 oth | |
| 700 | 1 | |a Hong, Suk-Kyung |e investigator |4 oth | |
| 700 | 1 | |a Cho, Woo Hyun |e investigator |4 oth | |
| 700 | 1 | |a Kwak, Sang Hyun |e investigator |4 oth | |
| 700 | 1 | |a Lee, Heung Bum |e investigator |4 oth | |
| 700 | 1 | |a Ahn, Jong-Joon |e investigator |4 oth | |
| 700 | 1 | |a Seong, Gil Myeong |e investigator |4 oth | |
| 700 | 1 | |a Lee, Song-I |e investigator |4 oth | |
| 700 | 1 | |a Park, Tai Sun |e investigator |4 oth | |
| 700 | 1 | |a Lee, Su Hwan |e investigator |4 oth | |
| 700 | 1 | |a Choi, Eun Young |e investigator |4 oth | |
| 700 | 1 | |a Moon, Jae Young |e investigator |4 oth | |
| 700 | 1 | |a Kang, Hyung Koo |e investigator |4 oth | |
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