A propensity score-integrated approach for leveraging external data in a randomized controlled trial with time-to-event endpoints
© 2024 Pharmaceutical Statistics. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA..
In a randomized controlled trial with time-to-event endpoint, some commonly used statistical tests to test for various aspects of survival differences, such as survival probability at a fixed time point, survival function up to a specific time point, and restricted mean survival time, may not be directly applicable when external data are leveraged to augment an arm (or both arms) of an RCT. In this paper, we propose a propensity score-integrated approach to extend such tests when external data are leveraged. Simulation studies are conducted to evaluate the operating characteristics of three propensity score-integrated statistical tests, and an illustrative example is given to demonstrate how these proposed procedures can be implemented.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Pharmaceutical statistics - (2024) vom: 05. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Wei-Chen [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Revised 05.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1002/pst.2377 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369327470 |
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| 520 | |a In a randomized controlled trial with time-to-event endpoint, some commonly used statistical tests to test for various aspects of survival differences, such as survival probability at a fixed time point, survival function up to a specific time point, and restricted mean survival time, may not be directly applicable when external data are leveraged to augment an arm (or both arms) of an RCT. In this paper, we propose a propensity score-integrated approach to extend such tests when external data are leveraged. Simulation studies are conducted to evaluate the operating characteristics of three propensity score-integrated statistical tests, and an illustrative example is given to demonstrate how these proposed procedures can be implemented | ||
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| 700 | 1 | |a Lu, Nelson |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chenguang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Heng |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Changhong |e verfasserin |4 aut | |
| 700 | 1 | |a Tiwari, Ram |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Yunling |e verfasserin |4 aut | |
| 700 | 1 | |a Yue, Lilly Q |e verfasserin |4 aut | |
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