Health Status Progression Measured Using Weekly Telemonitoring of COPD Assessment Test Scores Over 1 Year and Its Association With COPD Exacerbations
JCOPDF © 2024..
Background: A previous longitudinal study of chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) score changes suggested patients fall into 3 patterns: stable, improving, and worsening. This study assessed the evolution of CAT scores over time and its relationship to exacerbations.
Methods: In total, 84 participants used a telemedicine platform to complete CAT weekly for 52 weeks. Completion rates, annualized change in CAT scores, and learning effects were measured, as well as CAT changes of >4 units during look-back periods of 4 and 8 weeks. In a subgroup of participants with at least a 25% completion rate (adherent group, n=68 [81%]), the relationship between change in CAT score and exacerbations at any time during the study was examined post hoc.
Results: Linear regression showed that 50%, 22%, and 28% of the adherent subgroup had CAT scores indicating worsening, stable, and improving health status, respectively. In the adherent subgroup, 70% (n=7/10) of participants who had an exacerbation during the study had worsening CAT scores, versus 47% (n=27/58) without an exacerbation. The hazard ratio association between CAT score increase and moderate exacerbation was 1.13 (95% confidence interval: 1.03-1.24). Most participants experienced at least one CAT score change of >4 units, and 7% showed an initial learning effect with a median of 2 weeks.
Conclusion: Measuring trends in CAT scores may allow future studies to group patients into 3 defined categories of change over time and quantify CAT change trajectories to assess treatment response and potentially predict medium-term outcomes within individual patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Chronic obstructive pulmonary diseases (Miami, Fla.) - 11(2024), 2 vom: 26. März, Seite 144-154 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jones, Paul [VerfasserIn] |
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| Links: |
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| Themen: |
CAT score |
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| Anmerkungen: |
Date Revised 26.03.2024 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.15326/jcopdf.2023.0415 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369319915 |
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| 520 | |a Background: A previous longitudinal study of chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) score changes suggested patients fall into 3 patterns: stable, improving, and worsening. This study assessed the evolution of CAT scores over time and its relationship to exacerbations | ||
| 520 | |a Methods: In total, 84 participants used a telemedicine platform to complete CAT weekly for 52 weeks. Completion rates, annualized change in CAT scores, and learning effects were measured, as well as CAT changes of >4 units during look-back periods of 4 and 8 weeks. In a subgroup of participants with at least a 25% completion rate (adherent group, n=68 [81%]), the relationship between change in CAT score and exacerbations at any time during the study was examined post hoc | ||
| 520 | |a Results: Linear regression showed that 50%, 22%, and 28% of the adherent subgroup had CAT scores indicating worsening, stable, and improving health status, respectively. In the adherent subgroup, 70% (n=7/10) of participants who had an exacerbation during the study had worsening CAT scores, versus 47% (n=27/58) without an exacerbation. The hazard ratio association between CAT score increase and moderate exacerbation was 1.13 (95% confidence interval: 1.03-1.24). Most participants experienced at least one CAT score change of >4 units, and 7% showed an initial learning effect with a median of 2 weeks | ||
| 520 | |a Conclusion: Measuring trends in CAT scores may allow future studies to group patients into 3 defined categories of change over time and quantify CAT change trajectories to assess treatment response and potentially predict medium-term outcomes within individual patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CAT score | |
| 650 | 4 | |a COPD | |
| 650 | 4 | |a exacerbations | |
| 650 | 4 | |a patient-reported outcome | |
| 650 | 4 | |a telemonitoring | |
| 700 | 1 | |a Soutome, Toru |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuki, Taizo |e verfasserin |4 aut | |
| 700 | 1 | |a Shinoda, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hataji, Osamu |e verfasserin |4 aut | |
| 700 | 1 | |a Miura, Motohiko |e verfasserin |4 aut | |
| 700 | 1 | |a Kinoshita, Masaharu |e verfasserin |4 aut | |
| 700 | 1 | |a Mizoo, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Tobino, Kazunori |e verfasserin |4 aut | |
| 700 | 1 | |a Nishi, Takanobu |e verfasserin |4 aut | |
| 700 | 1 | |a Ishii, Takeo |e verfasserin |4 aut | |
| 700 | 1 | |a Shibata, Yoko |e verfasserin |4 aut | |
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