Urothelial carcinoma occurring in a defunctionalized bladder after urinary diversion due to the bladder exstrophy-epispadias complex
© 2023 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association..
Introduction: The bladder exstrophy-epispadias complex is a rare congenital disease. Urothelial carcinomas rarely occur in patients with this disease, and there have been few reports on its treatment.
Case presentation: We report the case of a 44-year-old man with a hemorrhage from the external urethral meatus. He was diagnosed with bladder exstrophy-epispadias complex and underwent urinary diversion with substitution cystoplasty and Mitrofanoff appendicovesicostomy. Because computed tomography and magnetic resonance imaging suggested invasive bladder carcinoma in the defunctionalized bladder, we performed a cystectomy. The patient was diagnosed with urothelial carcinoma with glandular differentiation. One month after the surgery, nivolumab adjuvant chemotherapy was administered. The patient showed no signs of recurrence or metastasis after the treatment.
Conclusion: This is the first case of adjuvant nivolumab therapy for urothelial carcinoma with the bladder exstrophy-epispadias complex.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
IJU case reports - 7(2024), 2 vom: 28. März, Seite 101-104 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Morikawa, Toshiharu [VerfasserIn] |
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| Links: |
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| Themen: |
Bladder exstrophy |
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| Anmerkungen: |
Date Revised 06.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1002/iju5.12675 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369305809 |
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| 100 | 1 | |a Morikawa, Toshiharu |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Urothelial carcinoma occurring in a defunctionalized bladder after urinary diversion due to the bladder exstrophy-epispadias complex |
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| 500 | |a Date Revised 06.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association. | ||
| 520 | |a Introduction: The bladder exstrophy-epispadias complex is a rare congenital disease. Urothelial carcinomas rarely occur in patients with this disease, and there have been few reports on its treatment | ||
| 520 | |a Case presentation: We report the case of a 44-year-old man with a hemorrhage from the external urethral meatus. He was diagnosed with bladder exstrophy-epispadias complex and underwent urinary diversion with substitution cystoplasty and Mitrofanoff appendicovesicostomy. Because computed tomography and magnetic resonance imaging suggested invasive bladder carcinoma in the defunctionalized bladder, we performed a cystectomy. The patient was diagnosed with urothelial carcinoma with glandular differentiation. One month after the surgery, nivolumab adjuvant chemotherapy was administered. The patient showed no signs of recurrence or metastasis after the treatment | ||
| 520 | |a Conclusion: This is the first case of adjuvant nivolumab therapy for urothelial carcinoma with the bladder exstrophy-epispadias complex | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a bladder exstrophy | |
| 650 | 4 | |a carcinoma, transitional | |
| 650 | 4 | |a chemotherapy, adjuvant | |
| 650 | 4 | |a epispadias | |
| 650 | 4 | |a nivolumab | |
| 650 | 4 | |a urinary diversion | |
| 700 | 1 | |a Iwatsuki, Shoichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Naiki-Ito, Aya |e verfasserin |4 aut | |
| 700 | 1 | |a Gonda, Masakazu |e verfasserin |4 aut | |
| 700 | 1 | |a Taguchi, Kazumi |e verfasserin |4 aut | |
| 700 | 1 | |a Naiki, Taku |e verfasserin |4 aut | |
| 700 | 1 | |a Hamamoto, Shuzo |e verfasserin |4 aut | |
| 700 | 1 | |a Okada, Atsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Yasui, Takahiro |e verfasserin |4 aut | |
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