Consequences of kidney donation by age in Japanese living kidney donors : a single-center study
© 2024. The Author(s), under exclusive licence to Japanese Society of Nephrology..
BACKGROUND: Elderly living kidney donors (LKDs) are becoming increasingly important in countries with a high prevalence of living-donor kidney transplants and an aging society. This study explored the features of elderly LKDs, focusing on their subsequent outcomes.
METHODS: This single-center, retrospective, observational study included eligible LKDs who donated their kidneys between April 2008 and July 2022. LKDs were categorized into an elderly (≥70 years at donation) or a non-elderly group (<70 years). We examined pre-operative characteristics and post-operative outcomes, such as kidney function, complications, development of end-stage kidney disease (ESKD), and mortality.
RESULTS: Of the 188 LKDs observed for a median of 5.7 years, 31 were in the elderly group (16.5%) and 157 (83.5%) were in the non-elderly group (mean age 72.5 ± 2.7 and 58.2 ± 7.3 years, respectively). No significant differences were observed in hospital stay length or peri-operative complications between groups. Both groups experienced a similar decline in post-donation estimated glomerular filtration rate (eGFR)-approximately 37%. In the elderly group, four LKDs died, and one progressed to ESKD. In the non-elderly group, two LKDs died, and none progressed to ESKD. The cause of death was not strongly suspected to be associated with the donation.
CONCLUSIONS: eGFR was maintained even in elderly LKDs post-donation. Prioritizing LKDs' safety is paramount; however, donations from elderly people would be acceptable, considering their life expectancy. This can expand the pool of living kidney donors and address the growing demand for kidney transplants.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Clinical and experimental nephrology - (2024) vom: 04. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ogata, Masatomo [VerfasserIn] |
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| Links: |
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| Themen: |
Elderly |
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| Anmerkungen: |
Date Revised 04.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1007/s10157-024-02476-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369267648 |
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| 520 | |a © 2024. The Author(s), under exclusive licence to Japanese Society of Nephrology. | ||
| 520 | |a BACKGROUND: Elderly living kidney donors (LKDs) are becoming increasingly important in countries with a high prevalence of living-donor kidney transplants and an aging society. This study explored the features of elderly LKDs, focusing on their subsequent outcomes | ||
| 520 | |a METHODS: This single-center, retrospective, observational study included eligible LKDs who donated their kidneys between April 2008 and July 2022. LKDs were categorized into an elderly (≥70 years at donation) or a non-elderly group (<70 years). We examined pre-operative characteristics and post-operative outcomes, such as kidney function, complications, development of end-stage kidney disease (ESKD), and mortality | ||
| 520 | |a RESULTS: Of the 188 LKDs observed for a median of 5.7 years, 31 were in the elderly group (16.5%) and 157 (83.5%) were in the non-elderly group (mean age 72.5 ± 2.7 and 58.2 ± 7.3 years, respectively). No significant differences were observed in hospital stay length or peri-operative complications between groups. Both groups experienced a similar decline in post-donation estimated glomerular filtration rate (eGFR)-approximately 37%. In the elderly group, four LKDs died, and one progressed to ESKD. In the non-elderly group, two LKDs died, and none progressed to ESKD. The cause of death was not strongly suspected to be associated with the donation | ||
| 520 | |a CONCLUSIONS: eGFR was maintained even in elderly LKDs post-donation. Prioritizing LKDs' safety is paramount; however, donations from elderly people would be acceptable, considering their life expectancy. This can expand the pool of living kidney donors and address the growing demand for kidney transplants | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Elderly | |
| 650 | 4 | |a Elderly donor | |
| 650 | 4 | |a Kidney transplantation | |
| 650 | 4 | |a Living kidney donor | |
| 650 | 4 | |a Peri-operative complications | |
| 700 | 1 | |a Osako, Kiyomi |e verfasserin |4 aut | |
| 700 | 1 | |a Terashita, Maho |e verfasserin |4 aut | |
| 700 | 1 | |a Miyauchi, Takamasa |e verfasserin |4 aut | |
| 700 | 1 | |a Sakurai, Yuko |e verfasserin |4 aut | |
| 700 | 1 | |a Shinoda, Kazunobu |e verfasserin |4 aut | |
| 700 | 1 | |a Sasaki, Hideo |e verfasserin |4 aut | |
| 700 | 1 | |a Shibagaki, Yugo |e verfasserin |4 aut | |
| 700 | 1 | |a Yazawa, Masahiko |e verfasserin |4 aut | |
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