Reduced plasma calcitonin gene-related peptide level identified in cluster headache : A prospective and controlled study
BACKGROUND: The role of calcitonin gene-related peptide (CGRP) in the cyclic pattern of cluster headache is unclear. To acquire biological insight and to comprehend why only episodic cluster headache responds to CGRP monoclonal antibodies, we examined whether plasma CGRP changes between disease states (i.e. bout, remission and chronic) and controls.
METHODS: The present study is a prospective case-control study. Participants with episodic cluster headache were sampled twice (bout and remission). Participants with chronic cluster headache and controls were sampled once. CGRP concentrations were measured in plasma with a validated radioimmunoassay.
RESULTS: Plasma was collected from 201 participants diagnosed with cluster headache according to the International Classification of Headache Disorders, 3rd edition, and from 100 age- and sex-matched controls. Overall, plasma CGRP levels were significantly lower in participants with cluster headache compared to controls (p < 0.05). In episodic cluster headache, CGRP levels were higher in bout than in remission (mean difference: 17.1 pmol/L, 95% confidence interval = 9.8-24.3, p < 0.0001). CGRP levels in bout were not different from chronic cluster headache (p = 0.266).
CONCLUSIONS: Plasma CGRP is unsuitable as a diagnostic biomarker of cluster headache or its disease states. The identified reduced CGRP levels suggest that CGRPs role in cluster headache is highly complex and future investigations are needed into the modulation of CGRP and its receptors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
Cephalalgia : an international journal of headache - 44(2024), 3 vom: 26. März, Seite 3331024231223970 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Petersen, Anja Sofie [VerfasserIn] |
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| Links: |
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| Themen: |
Bout |
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| Anmerkungen: |
Date Completed 05.03.2024 Date Revised 25.03.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1177/03331024231223970 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Petersen, Anja Sofie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Reduced plasma calcitonin gene-related peptide level identified in cluster headache |b A prospective and controlled study |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The role of calcitonin gene-related peptide (CGRP) in the cyclic pattern of cluster headache is unclear. To acquire biological insight and to comprehend why only episodic cluster headache responds to CGRP monoclonal antibodies, we examined whether plasma CGRP changes between disease states (i.e. bout, remission and chronic) and controls | ||
| 520 | |a METHODS: The present study is a prospective case-control study. Participants with episodic cluster headache were sampled twice (bout and remission). Participants with chronic cluster headache and controls were sampled once. CGRP concentrations were measured in plasma with a validated radioimmunoassay | ||
| 520 | |a RESULTS: Plasma was collected from 201 participants diagnosed with cluster headache according to the International Classification of Headache Disorders, 3rd edition, and from 100 age- and sex-matched controls. Overall, plasma CGRP levels were significantly lower in participants with cluster headache compared to controls (p < 0.05). In episodic cluster headache, CGRP levels were higher in bout than in remission (mean difference: 17.1 pmol/L, 95% confidence interval = 9.8-24.3, p < 0.0001). CGRP levels in bout were not different from chronic cluster headache (p = 0.266) | ||
| 520 | |a CONCLUSIONS: Plasma CGRP is unsuitable as a diagnostic biomarker of cluster headache or its disease states. The identified reduced CGRP levels suggest that CGRPs role in cluster headache is highly complex and future investigations are needed into the modulation of CGRP and its receptors | ||
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| 700 | 1 | |a Lund, Nunu |e verfasserin |4 aut | |
| 700 | 1 | |a Meßlinger, Karl |e verfasserin |4 aut | |
| 700 | 1 | |a Christensen, Sarah Louise |e verfasserin |4 aut | |
| 700 | 1 | |a Barloese, Mads |e verfasserin |4 aut | |
| 700 | 1 | |a Jørgensen, Niklas Rye |e verfasserin |4 aut | |
| 700 | 1 | |a Kogelman, Lisette |e verfasserin |4 aut | |
| 700 | 1 | |a Jensen, Rigmor Højland |e verfasserin |4 aut | |
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