Human respiratory syncytial virus subgroups A and B outbreak in a kindergarten in Zhejiang Province, China, 2023
Copyright © 2024 Liu, Pan, Chen, Ye, Chen, Wen, Wu, Wu, Qi, Chan, Sun, Yu, Zhang, Yan and Jiang..
Background: In May-June 2023, an unprecedented outbreak of human respiratory syncytial virus (HRSV) infections occurred in a kindergarten, Zhejiang Province, China. National, provincial, and local public health officials investigated the cause of the outbreak and instituted actions to control its spread.
Methods: We interviewed patients with the respiratory symptoms by questionnaire. Respiratory samples were screened for six respiratory pathogens by real-time quantitative polymerase chain reaction (RT-PCR). The confirmed cases were further sequenced of G gene to confirm the HRSV genotype. A phylogenetic tree was reconstructed by maximum likelihood method.
Results: Of the 103 children in the kindergarten, 45 were classified as suspected cases, and 25 cases were confirmed by RT-PCR. All confirmed cases were identified from half of classes. 36% (9/25) were admitted to hospital, none died. The attack rate was 53.19%. The median ages of suspected and confirmed cases were 32.7 months and 35.8 months, respectively. Nine of 27 confirmed cases lived in one community. Only two-family clusters among 88 household contacts were HRSV positive. A total of 18 of the G gene were obtained from the confirmed cases. Phylogenetic analyses revealed that 16 of the sequences belonged to the HRSV B/BA9 genotype, and the other 2 sequences belonged to the HRSV A/ON1 genotype. The school were closed on June 9 and the outbreak ended on June 15.
Conclusion: These findings suggest the need for an increased awareness of HRSV coinfections outbreak in the kindergarten, when HRSV resurges in the community after COVID-19 pandemic.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Frontiers in public health - 12(2024) vom: 14., Seite 1368744 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Shelan [VerfasserIn] |
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| Links: |
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| Themen: |
Attack rate |
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| Anmerkungen: |
Date Completed 05.03.2024 Date Revised 05.03.2024 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fpubh.2024.1368744 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM36925161X |
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| 520 | |a Copyright © 2024 Liu, Pan, Chen, Ye, Chen, Wen, Wu, Wu, Qi, Chan, Sun, Yu, Zhang, Yan and Jiang. | ||
| 520 | |a Background: In May-June 2023, an unprecedented outbreak of human respiratory syncytial virus (HRSV) infections occurred in a kindergarten, Zhejiang Province, China. National, provincial, and local public health officials investigated the cause of the outbreak and instituted actions to control its spread | ||
| 520 | |a Methods: We interviewed patients with the respiratory symptoms by questionnaire. Respiratory samples were screened for six respiratory pathogens by real-time quantitative polymerase chain reaction (RT-PCR). The confirmed cases were further sequenced of G gene to confirm the HRSV genotype. A phylogenetic tree was reconstructed by maximum likelihood method | ||
| 520 | |a Results: Of the 103 children in the kindergarten, 45 were classified as suspected cases, and 25 cases were confirmed by RT-PCR. All confirmed cases were identified from half of classes. 36% (9/25) were admitted to hospital, none died. The attack rate was 53.19%. The median ages of suspected and confirmed cases were 32.7 months and 35.8 months, respectively. Nine of 27 confirmed cases lived in one community. Only two-family clusters among 88 household contacts were HRSV positive. A total of 18 of the G gene were obtained from the confirmed cases. Phylogenetic analyses revealed that 16 of the sequences belonged to the HRSV B/BA9 genotype, and the other 2 sequences belonged to the HRSV A/ON1 genotype. The school were closed on June 9 and the outbreak ended on June 15 | ||
| 520 | |a Conclusion: These findings suggest the need for an increased awareness of HRSV coinfections outbreak in the kindergarten, when HRSV resurges in the community after COVID-19 pandemic | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a HRSV genotype B | |
| 650 | 4 | |a attack rate | |
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| 650 | 4 | |a human respiratory syncytial virus (HRSV) genotype A | |
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| 700 | 1 | |a Pan, Jinren |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yin |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Enfu |e verfasserin |4 aut | |
| 700 | 1 | |a Wen, Xiaosha |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Wenjie |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Bing |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Xiaoqi |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Ta-Chien |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Wanwan |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Zhao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Tongjie |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Jianbo |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Jianmin |e verfasserin |4 aut | |
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