Comparison of virus-neutralizing and virus-specific ELISA antibody responses among bovine neonates differentially primed and boosted against bovine coronavirus
Copyright and/or publishing rights held by the Canadian Veterinary Medical Association..
Objective: This study addressed the current gap in knowledge of neonatal prime-boost immune responses for the control of bovine coronavirus (BCoV) respiratory disease in weaning-age beef cattle.
Animals: Study 1 and Study 2 had 33 and 22 commercial cross neonatal beef calves, respectively.
Procedures: Study 1 compared BCoV-neutralizing antibody concentrations of control calves with 3 groups of calves differentially vaccinated with mucosal and/or systemic BCoV modified live virus (MLV) vaccines. Study 2 compared specific and neutralizing antibody concentrations among mucosally BCoV primed groups of calves that were differentially systemically boosted.
Results: In Study 1, calves that were mucosally primed and systemically boosted had higher BCoV-neutralizing antibody concentrations than the control group at weaning. In Study 2, boosting mucosally primed calves by injecting inactivated or MLV vaccine resulted in anamnestic BCoV-specific antibody responses at weaning.
Conclusion: Neonatal mucosal priming and systemic boosting resulted in anamnestic BCoV antibody responses at weaning.
Clinical relevance: Prime-boost vaccination should be considered for control of BCoV respiratory disease.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:65 |
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| Enthalten in: |
The Canadian veterinary journal = La revue veterinaire canadienne - 65(2024), 3 vom: 01. März, Seite 250-258 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Erickson, Nathan E N [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 05.03.2024 Date Revised 05.03.2024 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369240391 |
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| 100 | 1 | |a Erickson, Nathan E N |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparison of virus-neutralizing and virus-specific ELISA antibody responses among bovine neonates differentially primed and boosted against bovine coronavirus |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 05.03.2024 | ||
| 500 | |a Date Revised 05.03.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright and/or publishing rights held by the Canadian Veterinary Medical Association. | ||
| 520 | |a Objective: This study addressed the current gap in knowledge of neonatal prime-boost immune responses for the control of bovine coronavirus (BCoV) respiratory disease in weaning-age beef cattle | ||
| 520 | |a Animals: Study 1 and Study 2 had 33 and 22 commercial cross neonatal beef calves, respectively | ||
| 520 | |a Procedures: Study 1 compared BCoV-neutralizing antibody concentrations of control calves with 3 groups of calves differentially vaccinated with mucosal and/or systemic BCoV modified live virus (MLV) vaccines. Study 2 compared specific and neutralizing antibody concentrations among mucosally BCoV primed groups of calves that were differentially systemically boosted | ||
| 520 | |a Results: In Study 1, calves that were mucosally primed and systemically boosted had higher BCoV-neutralizing antibody concentrations than the control group at weaning. In Study 2, boosting mucosally primed calves by injecting inactivated or MLV vaccine resulted in anamnestic BCoV-specific antibody responses at weaning | ||
| 520 | |a Conclusion: Neonatal mucosal priming and systemic boosting resulted in anamnestic BCoV antibody responses at weaning | ||
| 520 | |a Clinical relevance: Prime-boost vaccination should be considered for control of BCoV respiratory disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antibodies, Neutralizing |2 NLM | |
| 650 | 7 | |a Vaccines, Attenuated |2 NLM | |
| 700 | 1 | |a Lacoste, Stacey |e verfasserin |4 aut | |
| 700 | 1 | |a Sniatynski, Michelle |e verfasserin |4 aut | |
| 700 | 1 | |a Waldner, Cheryl |e verfasserin |4 aut | |
| 700 | 1 | |a Ellis, John |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Canadian veterinary journal = La revue veterinaire canadienne |d 1960 |g 65(2024), 3 vom: 01. März, Seite 250-258 |w (DE-627)NLM000274410 |x 0008-5286 |7 nnns |
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