Suspected malnutrition-induced reversible feline skin fragility syndrome in a cat with congenital axial deformities
Copyright and/or publishing rights held by the Canadian Veterinary Medical Association..
A stray cat, an intact female Japanese domestic shorthair cat of unknown age (suspected to be a young adult), was rescued. The cat was lethargic and thin and had marked skin fragility, delayed wound healing without skin hyperextensibility, and hind limb proprioceptive ataxia and paresis. Survey radiography, computed tomography, and magnetic resonance imaging revealed congenital vertebral anomalies, including thoracolumbar transitional vertebrae, scoliosis resulting from a thoracic lateral wedge-shaped vertebra, and a kinked tail, and a dilated spinal cord central canal. Through nutritional support, the cat's general condition normalized, followed by a gradual and complete improvement of skin features. Whole-genome sequencing was completed; however, no pathogenic genetic variant was identified that could have caused this phenotype, including congenital scoliosis. A skin biopsy obtained 7 y after the rescue revealed no remarkable findings on histopathology or transmission electron microscopy. Based on clinical course and microscopic findings, malnutrition-induced reversible feline skin fragility syndrome (FSFS) was suspected, and nutritional support was considered to have improved the skin condition. Key clinical message: This is the second reported case of presumed malnutrition-induced reversible FSFS and was accompanied by long-term follow-up.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:65 |
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| Enthalten in: |
The Canadian veterinary journal = La revue veterinaire canadienne - 65(2024), 3 vom: 25. März, Seite 227-233 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yu, Yoshihiko [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 05.03.2024 Date Revised 05.03.2024 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369240340 |
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| 245 | 1 | 0 | |a Suspected malnutrition-induced reversible feline skin fragility syndrome in a cat with congenital axial deformities |
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| 500 | |a Date Revised 05.03.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright and/or publishing rights held by the Canadian Veterinary Medical Association. | ||
| 520 | |a A stray cat, an intact female Japanese domestic shorthair cat of unknown age (suspected to be a young adult), was rescued. The cat was lethargic and thin and had marked skin fragility, delayed wound healing without skin hyperextensibility, and hind limb proprioceptive ataxia and paresis. Survey radiography, computed tomography, and magnetic resonance imaging revealed congenital vertebral anomalies, including thoracolumbar transitional vertebrae, scoliosis resulting from a thoracic lateral wedge-shaped vertebra, and a kinked tail, and a dilated spinal cord central canal. Through nutritional support, the cat's general condition normalized, followed by a gradual and complete improvement of skin features. Whole-genome sequencing was completed; however, no pathogenic genetic variant was identified that could have caused this phenotype, including congenital scoliosis. A skin biopsy obtained 7 y after the rescue revealed no remarkable findings on histopathology or transmission electron microscopy. Based on clinical course and microscopic findings, malnutrition-induced reversible feline skin fragility syndrome (FSFS) was suspected, and nutritional support was considered to have improved the skin condition. Key clinical message: This is the second reported case of presumed malnutrition-induced reversible FSFS and was accompanied by long-term follow-up | ||
| 650 | 4 | |a Case Reports | |
| 700 | 1 | |a Miyamoto, Tadashi |e verfasserin |4 aut | |
| 700 | 1 | |a Kimura, Yui |e verfasserin |4 aut | |
| 700 | 1 | |a Itamoto, Kazuhito |e verfasserin |4 aut | |
| 700 | 1 | |a Michishita, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Hatakeyama, Hitoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Nagashima, Tomokazu |e verfasserin |4 aut | |
| 700 | 1 | |a Asada, Rikako |e verfasserin |4 aut | |
| 700 | 1 | |a Yamaguchi, Tomomi |e verfasserin |4 aut | |
| 700 | 1 | |a Hasegawa, Daisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Nomura, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Lyons, Leslie A |e verfasserin |4 aut | |
| 700 | 1 | |a Kosho, Tomoki |e verfasserin |4 aut | |
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