Inflammatory marker profiles and in-hospital neurological deterioration in patients with acute minor ischemic stroke
© 2024 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd..
AIM: The aim of the study was to analyze the association between inflammatory marker profiles and in-hospital neurological deterioration (ND) in acute ischemic stroke (AIS) patients.
METHODS: Data from patients with minor AIS from the Third China National Stroke Registry were analyzed. Inflammatory cytokine levels within 24 h of admission were measured. The primary outcome was in-hospital ND (an increase in National Institutes of Health Stroke Scale score ≥4 from admission to discharge). Associations were evaluated using odds ratios (ORs) and 95% confidence intervals (CIs) derived from logistic regression models. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were used to evaluate incremental predictive values.
RESULTS: A total of 4031 patients (1246 women, 30.9%) with a median age of 62 years were included. In-hospital ND occurred in 121 patients (3%). Each standard-deviation increase in interleukin (IL)-6 (OR, 1.17 [95% CI, 1.06-1.31]) and high-sensitivity C-reactive protein (hsCRP) (OR, 1.43 [95% CI, 1.24-1.66]) levels was associated with increased in-hospital ND risk. Incremental predictive values for adding IL-6 (IDI, 0.012; NRI, 0.329) but not hsCRP levels to the conventional risk factors were found.
CONCLUSION: In minor AIS, hsCRP and IL-6 levels were associated with in-hospital ND, including IL-6 levels in prognostic models improved risk classification.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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Enthalten in: |
CNS neuroscience & therapeutics - 30(2024), 3 vom: 01. März, Seite e14648 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Yi, Luo [VerfasserIn] |
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Links: |
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Themen: |
9007-41-4 |
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Anmerkungen: |
Date Completed 05.03.2024 Date Revised 18.04.2024 published: Print Citation Status MEDLINE |
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doi: |
10.1111/cns.14648 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM369227425 |
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520 | |a © 2024 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. | ||
520 | |a AIM: The aim of the study was to analyze the association between inflammatory marker profiles and in-hospital neurological deterioration (ND) in acute ischemic stroke (AIS) patients | ||
520 | |a METHODS: Data from patients with minor AIS from the Third China National Stroke Registry were analyzed. Inflammatory cytokine levels within 24 h of admission were measured. The primary outcome was in-hospital ND (an increase in National Institutes of Health Stroke Scale score ≥4 from admission to discharge). Associations were evaluated using odds ratios (ORs) and 95% confidence intervals (CIs) derived from logistic regression models. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were used to evaluate incremental predictive values | ||
520 | |a RESULTS: A total of 4031 patients (1246 women, 30.9%) with a median age of 62 years were included. In-hospital ND occurred in 121 patients (3%). Each standard-deviation increase in interleukin (IL)-6 (OR, 1.17 [95% CI, 1.06-1.31]) and high-sensitivity C-reactive protein (hsCRP) (OR, 1.43 [95% CI, 1.24-1.66]) levels was associated with increased in-hospital ND risk. Incremental predictive values for adding IL-6 (IDI, 0.012; NRI, 0.329) but not hsCRP levels to the conventional risk factors were found | ||
520 | |a CONCLUSION: In minor AIS, hsCRP and IL-6 levels were associated with in-hospital ND, including IL-6 levels in prognostic models improved risk classification | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a acute ischemic stroke | |
650 | 4 | |a cerebrovascular disease | |
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700 | 1 | |a Jiang, Ying-Yu |e verfasserin |4 aut | |
700 | 1 | |a Jiang, Yong |e verfasserin |4 aut | |
700 | 1 | |a Meng, Xia |e verfasserin |4 aut | |
700 | 1 | |a Li, Hao |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Xing-Quan |e verfasserin |4 aut | |
700 | 1 | |a Wang, Yi-Long |e verfasserin |4 aut | |
700 | 1 | |a Liu, Li-Ping |e verfasserin |4 aut | |
700 | 1 | |a Wang, Yong-Jun |e verfasserin |4 aut | |
700 | 1 | |a Gu, Hong-Qiu |e verfasserin |4 aut | |
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