Long-term outcomes of 5-year survivors without recurrence after the complete resection of non-small cell lung cancer after lobectomy : a landmark analysis in consideration of competing risks
© 2024. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd..
PURPOSE: Among non-small cell lung cancers (NSCLC), 5 years is a benchmark in cancer control and treatment, but a certain percentage of cases recur after 5 years. The long-term post-recurrence outcomes remain controversial. To examine the accurate prognostic factors associated with survival and cancer recurrence among 5-year survivors, a landmark analysis that considered competing risks was performed.
METHODS: Complete resection of NSCLC was performed in 2482 patients between January 2003 and December 2015. A total of 1431 patients were 5-year survivors without recurrence. A landmark time analysis was applied to the overall survival (OS) and recurrence-free survival (RFS) from 5 years after surgery, and the findings were calculated using the Kaplan-Meier method. The cumulative incidence of cause-specific death and recurrence was estimated using the cumulative incidence function, while carefully considering the competing risks.
RESULTS: Postoperative recurrence was detected in 732 patients, of whom 68 (9.3%) had recurrence after 5 years. The median follow-up period was 8.2 years. In the competing risk analysis, the independent poor prognostic factors associated with cause-specific death were age ≥ 75 years, lymph node metastasis and pleural invasion.
CONCLUSIONS: Patients requiring a follow-up for > 5 years were aged ≥ 75 years and had either lymph node metastasis or pleural invasion.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Surgery today - (2024) vom: 02. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Koike, Yutaro [VerfasserIn] |
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| Links: |
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| Themen: |
5-year survivors |
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| Anmerkungen: |
Date Revised 02.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1007/s00595-024-02804-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369202538 |
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| 245 | 1 | 0 | |a Long-term outcomes of 5-year survivors without recurrence after the complete resection of non-small cell lung cancer after lobectomy |b a landmark analysis in consideration of competing risks |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2024. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd. | ||
| 520 | |a PURPOSE: Among non-small cell lung cancers (NSCLC), 5 years is a benchmark in cancer control and treatment, but a certain percentage of cases recur after 5 years. The long-term post-recurrence outcomes remain controversial. To examine the accurate prognostic factors associated with survival and cancer recurrence among 5-year survivors, a landmark analysis that considered competing risks was performed | ||
| 520 | |a METHODS: Complete resection of NSCLC was performed in 2482 patients between January 2003 and December 2015. A total of 1431 patients were 5-year survivors without recurrence. A landmark time analysis was applied to the overall survival (OS) and recurrence-free survival (RFS) from 5 years after surgery, and the findings were calculated using the Kaplan-Meier method. The cumulative incidence of cause-specific death and recurrence was estimated using the cumulative incidence function, while carefully considering the competing risks | ||
| 520 | |a RESULTS: Postoperative recurrence was detected in 732 patients, of whom 68 (9.3%) had recurrence after 5 years. The median follow-up period was 8.2 years. In the competing risk analysis, the independent poor prognostic factors associated with cause-specific death were age ≥ 75 years, lymph node metastasis and pleural invasion | ||
| 520 | |a CONCLUSIONS: Patients requiring a follow-up for > 5 years were aged ≥ 75 years and had either lymph node metastasis or pleural invasion | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 5-year survivors | |
| 650 | 4 | |a Cancer-specific death | |
| 650 | 4 | |a Competing risks | |
| 650 | 4 | |a Landmark analysis | |
| 650 | 4 | |a Overall survival | |
| 650 | 4 | |a Recurrence-free-survival | |
| 700 | 1 | |a Aokage, Keiju |e verfasserin |4 aut | |
| 700 | 1 | |a Wakabayashi, Masashi |e verfasserin |4 aut | |
| 700 | 1 | |a Ikeno, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Onodera, Ken |e verfasserin |4 aut | |
| 700 | 1 | |a Samejima, Joji |e verfasserin |4 aut | |
| 700 | 1 | |a Miyoshi, Tomohiro |e verfasserin |4 aut | |
| 700 | 1 | |a Tane, Kenta |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Kenji |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuboi, Masahiro |e verfasserin |4 aut | |
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