Antifungal Activity and Mechanism of 4-Propylphenol Against Fusarium graminearum, Agent of Wheat Scab, and Its Potential Application
Fusarium head blight (FHB), caused by Fusarium graminearum, is a predominant disease of wheat. Due to the lack of disease-resistant germplasm, chemical control is an important means to control wheat scab. Volatile substances produced in near-isogenic wheat lines were detected after inoculation with F. graminearum, and 4-propylphenol, which appears in FHB-resistant lines, was identified. In vitro and in vivo antifungal activity tests demonstrate that 4-propylphenol effectively inhibits the mycelial growth of F. graminearum. Metabolomics analysis showed changes in glutathione metabolism, indicating that 4-propylphenol triggered reactive oxygen species (ROS) stress. This was consistent with the increasing ROS levels in Fusarium cells treated with 4-propylphenol. Further results demonstrated that excessive accumulation of ROS induced DNA and cell membrane damage in the mycelium. Moreover, 4-propylphenol showed different degrees of inhibition against other soil-borne pathogens (fungi and oomycetes). These findings illustrated that 4-propylphenol has broad spectrum and high antifungal activity and should be considered for use as an ecological fungicide.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:72 |
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| Enthalten in: |
Journal of agricultural and food chemistry - 72(2024), 10 vom: 13. März, Seite 5258-5268 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sun, Shufang [VerfasserIn] |
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| Links: |
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| Themen: |
4-propylphenol |
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| Anmerkungen: |
Date Completed 14.03.2024 Date Revised 14.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acs.jafc.3c09646 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369200004 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Fusarium head blight (FHB), caused by Fusarium graminearum, is a predominant disease of wheat. Due to the lack of disease-resistant germplasm, chemical control is an important means to control wheat scab. Volatile substances produced in near-isogenic wheat lines were detected after inoculation with F. graminearum, and 4-propylphenol, which appears in FHB-resistant lines, was identified. In vitro and in vivo antifungal activity tests demonstrate that 4-propylphenol effectively inhibits the mycelial growth of F. graminearum. Metabolomics analysis showed changes in glutathione metabolism, indicating that 4-propylphenol triggered reactive oxygen species (ROS) stress. This was consistent with the increasing ROS levels in Fusarium cells treated with 4-propylphenol. Further results demonstrated that excessive accumulation of ROS induced DNA and cell membrane damage in the mycelium. Moreover, 4-propylphenol showed different degrees of inhibition against other soil-borne pathogens (fungi and oomycetes). These findings illustrated that 4-propylphenol has broad spectrum and high antifungal activity and should be considered for use as an ecological fungicide | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 4-propylphenol | |
| 650 | 4 | |a Fusarium graminearum | |
| 650 | 4 | |a botanical fungicide | |
| 650 | 4 | |a broad-spectrum | |
| 650 | 4 | |a volatile organic compounds (VOCs) | |
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| 650 | 7 | |a 4-propylphenol |2 NLM | |
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| 650 | 7 | |a Phenols |2 NLM | |
| 700 | 1 | |a Tang, Nawen |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Kun |e verfasserin |4 aut | |
| 700 | 1 | |a You, Jiahui |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Anru |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Qunqing |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Qian |e verfasserin |4 aut | |
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