Unraveling the cross-talk between N6-methyladenosine modification and non-coding RNAs in breast cancer : Mechanisms and clinical implications
© 2024 UICC..
In recent years, breast cancer (BC) has surpassed lung cancer as the most common malignant tumor worldwide and remains the leading cause of cancer death in women. The etiology of BC usually involves dysregulation of epigenetic mechanisms and aberrant expression of certain non-coding RNAs (ncRNAs). N6-methyladenosine (m6A), the most prevalent RNA modification in eukaryotes, widely exists in ncRNAs to affect its biosynthesis and function, and is an important regulator of tumor-related signaling pathways. Interestingly, ncRNAs can also regulate or target m6A modification, playing a key role in cancer progression. However, the m6A-ncRNAs regulatory network in BC has not been fully elucidated, especially the regulation of m6A modification by ncRNAs. Therefore, in this review, we comprehensively summarize the interaction mechanisms and biological significance of m6A modifications and ncRNAs in BC. Meanwhile, we also focused on the clinical application value of m6A modification in BC diagnosis and prognosis, intending to explore new biomarkers and potential therapeutic targets.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:154 |
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| Enthalten in: |
International journal of cancer - 154(2024), 11 vom: 01. Apr., Seite 1877-1889 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Xuan [VerfasserIn] |
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| Links: |
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| Themen: |
Adenosine |
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| Anmerkungen: |
Date Completed 03.04.2024 Date Revised 03.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/ijc.34900 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369197356 |
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| 245 | 1 | 0 | |a Unraveling the cross-talk between N6-methyladenosine modification and non-coding RNAs in breast cancer |b Mechanisms and clinical implications |
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| 500 | |a Date Revised 03.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024 UICC. | ||
| 520 | |a In recent years, breast cancer (BC) has surpassed lung cancer as the most common malignant tumor worldwide and remains the leading cause of cancer death in women. The etiology of BC usually involves dysregulation of epigenetic mechanisms and aberrant expression of certain non-coding RNAs (ncRNAs). N6-methyladenosine (m6A), the most prevalent RNA modification in eukaryotes, widely exists in ncRNAs to affect its biosynthesis and function, and is an important regulator of tumor-related signaling pathways. Interestingly, ncRNAs can also regulate or target m6A modification, playing a key role in cancer progression. However, the m6A-ncRNAs regulatory network in BC has not been fully elucidated, especially the regulation of m6A modification by ncRNAs. Therefore, in this review, we comprehensively summarize the interaction mechanisms and biological significance of m6A modifications and ncRNAs in BC. Meanwhile, we also focused on the clinical application value of m6A modification in BC diagnosis and prognosis, intending to explore new biomarkers and potential therapeutic targets | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a N6‐methyladenosine (m6A) | |
| 650 | 4 | |a breast cancer | |
| 650 | 4 | |a clinical application | |
| 650 | 4 | |a cross‐talk | |
| 650 | 4 | |a non‐coding RNA (ncRNA) | |
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| 700 | 1 | |a Xie, Xuelong |e verfasserin |4 aut | |
| 700 | 1 | |a Sui, Chentao |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xuexue |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Miao |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhan, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Jia |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jinbo |e verfasserin |4 aut | |
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