Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting
Copyright © 2024 Elsevier B.V. All rights reserved..
Muscle wasting diseases, such as cancer cachexia and age-associated sarcopenia, have a profound and detrimental impact on functional independence, quality of life, and survival. Our understanding of the underlying mechanisms is currently limited, which has significantly hindered the development of targeted therapies. In this study, we explored the possibility that the streptococcal quorum sensing peptide Competence Stimulating Peptide 7 (CSP-7) might be a previously unidentified contributor to clinical muscle wasting. We found that CSP-7 selectively triggers muscle cell inflammation in vitro, specifically the release of IL-6. Furthermore, we demonstrated that CSP-7 can traverse the gastrointestinal barrier in vitro and is present in the systemic circulation in humans in vivo. Importantly, CSP-7 was associated with a muscle wasting phenotype in mice in vivo. Overall, our findings provide new mechanistic insights into the pathophysiology of muscle inflammation and wasting.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1870 |
|---|---|
| Enthalten in: |
Biochimica et biophysica acta. Molecular basis of disease - 1870(2024), 4 vom: 15. Apr., Seite 167094 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
De Spiegeleer, Anton [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
CSP-7 |
|---|
| Anmerkungen: |
Date Completed 08.04.2024 Date Revised 08.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.bbadis.2024.167094 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM369185625 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM369185625 | ||
| 003 | DE-627 | ||
| 005 | 20240408232513.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240302s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.bbadis.2024.167094 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1369.xml |
| 035 | |a (DE-627)NLM369185625 | ||
| 035 | |a (NLM)38428683 | ||
| 035 | |a (PII)S0925-4439(24)00083-8 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a De Spiegeleer, Anton |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.04.2024 | ||
| 500 | |a Date Revised 08.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a Muscle wasting diseases, such as cancer cachexia and age-associated sarcopenia, have a profound and detrimental impact on functional independence, quality of life, and survival. Our understanding of the underlying mechanisms is currently limited, which has significantly hindered the development of targeted therapies. In this study, we explored the possibility that the streptococcal quorum sensing peptide Competence Stimulating Peptide 7 (CSP-7) might be a previously unidentified contributor to clinical muscle wasting. We found that CSP-7 selectively triggers muscle cell inflammation in vitro, specifically the release of IL-6. Furthermore, we demonstrated that CSP-7 can traverse the gastrointestinal barrier in vitro and is present in the systemic circulation in humans in vivo. Importantly, CSP-7 was associated with a muscle wasting phenotype in mice in vivo. Overall, our findings provide new mechanistic insights into the pathophysiology of muscle inflammation and wasting | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CSP-7 | |
| 650 | 4 | |a Competence stimulating peptide | |
| 650 | 4 | |a Human plasma | |
| 650 | 4 | |a LC-MS | |
| 650 | 4 | |a Microbiota | |
| 650 | 4 | |a Muscle wasting | |
| 650 | 4 | |a Peptide | |
| 650 | 4 | |a Quorum sensing peptide | |
| 650 | 4 | |a Sarcopenia | |
| 650 | 4 | |a cachexia | |
| 650 | 7 | |a Peptides |2 NLM | |
| 700 | 1 | |a Descamps, Amélie |e verfasserin |4 aut | |
| 700 | 1 | |a Wynendaele, Evelien |e verfasserin |4 aut | |
| 700 | 1 | |a Naumovski, Petar |e verfasserin |4 aut | |
| 700 | 1 | |a Crombez, Liesbeth |e verfasserin |4 aut | |
| 700 | 1 | |a Planas, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Feliu, Lidia |e verfasserin |4 aut | |
| 700 | 1 | |a Knappe, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Mouly, Vincent |e verfasserin |4 aut | |
| 700 | 1 | |a Bigot, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Bielza, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Hoffmann, Ralf |e verfasserin |4 aut | |
| 700 | 1 | |a Van Den Noortgate, Nele |e verfasserin |4 aut | |
| 700 | 1 | |a Elewaut, Dirk |e verfasserin |4 aut | |
| 700 | 1 | |a De Spiegeleer, Bart |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biochimica et biophysica acta. Molecular basis of disease |d 2017 |g 1870(2024), 4 vom: 15. Apr., Seite 167094 |w (DE-627)NLM260137588 |x 1879-260X |7 nnns |
| 773 | 1 | 8 | |g volume:1870 |g year:2024 |g number:4 |g day:15 |g month:04 |g pages:167094 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.bbadis.2024.167094 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 1870 |j 2024 |e 4 |b 15 |c 04 |h 167094 | ||