Restoring Treg/Th17 cell balance in ulcerative colitis through HRas silencing and MAPK pathway inhibition
Copyright © 2024 Elsevier B.V. All rights reserved..
This study investigates HRas-dependent mechanisms in the disruption of regulatory T (Treg) cells and T helper 17 (Th17) cells balance in ulcerative colitis (UC). Comprehensive RNA sequencing and bioinformatics analyses revealed elevated HRas and MAPK pathway-related protein expression in UC samples. Using a murine UC model induced by dextran sulfate sodium (DSS), HRas silencing was found to promote Treg cell differentiation and suppress Th17 cell production, effectively restoring balance. Inactivation of the MAPK pathway played a pivotal role in this rebalancing effect. In vivo experiments further confirmed that HRas silencing mitigated colon tissue damage in DSS-induced mice, emphasizing its potential as a therapeutic strategy for UC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 |
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| Enthalten in: |
International immunopharmacology - 130(2024) vom: 30. März, Seite 111608 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Siwei [VerfasserIn] |
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| Links: |
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| Themen: |
9042-14-2 |
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| Anmerkungen: |
Date Completed 25.03.2024 Date Revised 25.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.intimp.2024.111608 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369180267 |
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| 520 | |a This study investigates HRas-dependent mechanisms in the disruption of regulatory T (Treg) cells and T helper 17 (Th17) cells balance in ulcerative colitis (UC). Comprehensive RNA sequencing and bioinformatics analyses revealed elevated HRas and MAPK pathway-related protein expression in UC samples. Using a murine UC model induced by dextran sulfate sodium (DSS), HRas silencing was found to promote Treg cell differentiation and suppress Th17 cell production, effectively restoring balance. Inactivation of the MAPK pathway played a pivotal role in this rebalancing effect. In vivo experiments further confirmed that HRas silencing mitigated colon tissue damage in DSS-induced mice, emphasizing its potential as a therapeutic strategy for UC | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a HRas silencing | |
| 650 | 4 | |a MAPK pathway | |
| 650 | 4 | |a RNA sequencing | |
| 650 | 4 | |a Th17 cells | |
| 650 | 4 | |a Treg cells | |
| 650 | 4 | |a Treg/Th17 imbalance | |
| 650 | 4 | |a Ulcerative colitis | |
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| 700 | 1 | |a Wu, Xiaohan |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Weiguo |e verfasserin |4 aut | |
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