Effect of sheep bone protein hydrolysate on promoting calcium absorption and enhancing bone quality in low-calcium diet fed rats
Copyright © 2024 Elsevier Ltd. All rights reserved..
Calcium deficiency is prone to fractures, osteoporosis and other symptoms. In this study, sheep bone protein hydrolysates (SBPHs) were obtained by protease hydrolysis. A low-calcium-diet-induced calcium-deficiency rat model was established to investigate the effects of SBPHs on calcium absorption and intestinal flora composition. The results showed that an SBPHs + CaCl2 treatment significantly increased the bone calcium content, bone mineral density, trabecular bone volume, and trabecular thickness, and reduced trabecular separation, and changed the level of bone turnover markers (P < 0.05). Supplementation of SBPHs + CaCl2 can remarkably enhance the bone mechanical strength, and the microstructure of bone was improved, and the trabecular network was more continuous, complete, and thicker. Additionally, SBPHs + CaCl2 dietary increased the abundance of Firmicutes and reduced the abundance of Proteobacteria and Verrucomicrobiota, and promoted the production of short chain fatty acids. This study indicated that SBPHs promoted calcium absorption and could be applied to alleviate osteoporosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:446 |
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| Enthalten in: |
Food chemistry - 446(2024) vom: 15. Apr., Seite 138763 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hu, Guanhua [VerfasserIn] |
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| Links: |
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| Themen: |
Bone health |
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| Anmerkungen: |
Date Completed 03.04.2024 Date Revised 03.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.foodchem.2024.138763 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Calcium deficiency is prone to fractures, osteoporosis and other symptoms. In this study, sheep bone protein hydrolysates (SBPHs) were obtained by protease hydrolysis. A low-calcium-diet-induced calcium-deficiency rat model was established to investigate the effects of SBPHs on calcium absorption and intestinal flora composition. The results showed that an SBPHs + CaCl2 treatment significantly increased the bone calcium content, bone mineral density, trabecular bone volume, and trabecular thickness, and reduced trabecular separation, and changed the level of bone turnover markers (P < 0.05). Supplementation of SBPHs + CaCl2 can remarkably enhance the bone mechanical strength, and the microstructure of bone was improved, and the trabecular network was more continuous, complete, and thicker. Additionally, SBPHs + CaCl2 dietary increased the abundance of Firmicutes and reduced the abundance of Proteobacteria and Verrucomicrobiota, and promoted the production of short chain fatty acids. This study indicated that SBPHs promoted calcium absorption and could be applied to alleviate osteoporosis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bone health | |
| 650 | 4 | |a Calcium absorption | |
| 650 | 4 | |a Gut microbiota | |
| 650 | 4 | |a Low calcium diet | |
| 650 | 4 | |a Sheep bone protein hydrolysate | |
| 650 | 7 | |a Calcium |2 NLM | |
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| 650 | 7 | |a Protein Hydrolysates |2 NLM | |
| 650 | 7 | |a Calcium Chloride |2 NLM | |
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| 650 | 7 | |a Calcium, Dietary |2 NLM | |
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| 700 | 1 | |a Hao, Shiqi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiaotong |e verfasserin |4 aut | |
| 700 | 1 | |a Qian, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Dou, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Hou, Puxin |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Lihua |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Lina |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Ye |e verfasserin |4 aut | |
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