Effect of beta-cypermethrin on the reproductive capacity of female mice in advanced age
Copyright © 2024 Elsevier B.V. All rights reserved..
The aim of the present study was to investigate whether exposure to pesticides beta-cypermethrin (β-CYP) harms the reproductive capacity of advanced-age female mice. The results evidenced that peri-implantation β-CYP exposure significantly reduced the number of fetuses per advanced-age female in the first litter, and the number and weight of implantation sites. The levels of decidualization markers were significantly reduced in β-CYP-administered advanced-age mice. Lower expression of Pcna, Cdk6, Foxo1, Ki67, and p62 protein and mRNA was found in the decidua of β-CYP-treated advanced-age mice. The levels of Bax, cleaved caspase-3, Lc3a/b, Atg, mTOR, and p-mTOR protein, and the ratio of p-mTOR/mTOR protein expression were clearly downregulated by peri-implantation β-CYP exposure. These results indicated that peri-implantation β-CYP exposure may elevate the decline in reproductive capacity of early pregnant mice in advanced age.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:107 |
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| Enthalten in: |
Environmental toxicology and pharmacology - 107(2024) vom: 30. Apr., Seite 104410 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Qiao, Qian-Feng [VerfasserIn] |
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| Links: |
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| Themen: |
1TR49121NP |
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| Anmerkungen: |
Date Completed 16.04.2024 Date Revised 16.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.etap.2024.104410 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM369133838 |
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| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a The aim of the present study was to investigate whether exposure to pesticides beta-cypermethrin (β-CYP) harms the reproductive capacity of advanced-age female mice. The results evidenced that peri-implantation β-CYP exposure significantly reduced the number of fetuses per advanced-age female in the first litter, and the number and weight of implantation sites. The levels of decidualization markers were significantly reduced in β-CYP-administered advanced-age mice. Lower expression of Pcna, Cdk6, Foxo1, Ki67, and p62 protein and mRNA was found in the decidua of β-CYP-treated advanced-age mice. The levels of Bax, cleaved caspase-3, Lc3a/b, Atg, mTOR, and p-mTOR protein, and the ratio of p-mTOR/mTOR protein expression were clearly downregulated by peri-implantation β-CYP exposure. These results indicated that peri-implantation β-CYP exposure may elevate the decline in reproductive capacity of early pregnant mice in advanced age | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Advanced-age female mice | |
| 650 | 4 | |a Beta-cypermethrin | |
| 650 | 4 | |a Reproductive capacity | |
| 650 | 7 | |a cypermethrin |2 NLM | |
| 650 | 7 | |a 1TR49121NP |2 NLM | |
| 650 | 7 | |a Pyrethrins |2 NLM | |
| 650 | 7 | |a TOR Serine-Threonine Kinases |2 NLM | |
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| 700 | 1 | |a Wang, Li-Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, De-E |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Na |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Qiong-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Yong-Jiang |e verfasserin |4 aut | |
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