The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau : A systematic review and meta-analysis
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved..
Conflicting evidence exists on the relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) biomarkers. Therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated hemoglobin, fasting blood glucose, insulin resistance indices) and DM status with AD biomarkers of amyloid-β and tau measured by positron emission tomography or cerebrospinal fluid. We selected 37 studies from PubMed and Embase, including 11,694 individuals. More impaired glucose metabolism and DM status were associated with higher tau biomarkers (r=0.11[0.03-0.18], p=0.008; I2=68%), but were not associated with amyloid-β biomarkers (r=-0.06[-0.13-0.01], p=0.08; I2=81%). Meta-regression revealed that glucose metabolism and DM were specifically associated with tau biomarkers in population settings (p=0.001). Furthermore, more impaired glucose metabolism and DM status were associated with lower amyloid-β biomarkers in memory clinic settings (p=0.004), and in studies with a higher prevalence of dementia (p<0.001) or lower cognitive scores (p=0.04). These findings indicate that DM is associated with biomarkers of tau but not with amyloid-β. This knowledge is valuable for improving dementia and DM diagnostics and treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:159 |
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| Enthalten in: |
Neuroscience and biobehavioral reviews - 159(2024) vom: 28. März, Seite 105604 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
van Gils, Veerle [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.03.2024 Date Revised 20.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neubiorev.2024.105604 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369130952 |
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| 100 | 1 | |a van Gils, Veerle |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau |b A systematic review and meta-analysis |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a Conflicting evidence exists on the relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) biomarkers. Therefore, we conducted a random-effects meta-analysis to evaluate the correlation of glucose metabolism measures (glycated hemoglobin, fasting blood glucose, insulin resistance indices) and DM status with AD biomarkers of amyloid-β and tau measured by positron emission tomography or cerebrospinal fluid. We selected 37 studies from PubMed and Embase, including 11,694 individuals. More impaired glucose metabolism and DM status were associated with higher tau biomarkers (r=0.11[0.03-0.18], p=0.008; I2=68%), but were not associated with amyloid-β biomarkers (r=-0.06[-0.13-0.01], p=0.08; I2=81%). Meta-regression revealed that glucose metabolism and DM were specifically associated with tau biomarkers in population settings (p=0.001). Furthermore, more impaired glucose metabolism and DM status were associated with lower amyloid-β biomarkers in memory clinic settings (p=0.004), and in studies with a higher prevalence of dementia (p<0.001) or lower cognitive scores (p=0.04). These findings indicate that DM is associated with biomarkers of tau but not with amyloid-β. This knowledge is valuable for improving dementia and DM diagnostics and treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Amyloid-beta | |
| 650 | 4 | |a Cerebrospinal fluid (CSF) | |
| 650 | 4 | |a Elderly persons | |
| 650 | 4 | |a Fasting blood glucose (FBG) | |
| 650 | 4 | |a Glycated hemoglobin (HbA1c) | |
| 650 | 4 | |a Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) | |
| 650 | 4 | |a Mini Mental Status Examination (MMSE) | |
| 650 | 4 | |a Positron emission tomography (PET) | |
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| 650 | 7 | |a tau Proteins |2 NLM | |
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| 700 | 1 | |a Côté, Jade |e verfasserin |4 aut | |
| 700 | 1 | |a Viechtbauer, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Fanelli, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Salas-Salvadó, Jordi |e verfasserin |4 aut | |
| 700 | 1 | |a Wimberley, Theresa |e verfasserin |4 aut | |
| 700 | 1 | |a Bulló, Mònica |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez-Aranda, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Dalsgaard, Søren |e verfasserin |4 aut | |
| 700 | 1 | |a Visser, Pieter Jelle |e verfasserin |4 aut | |
| 700 | 1 | |a Jansen, Willemijn J |e verfasserin |4 aut | |
| 700 | 1 | |a Vos, Stephanie J B |e verfasserin |4 aut | |
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