Prevotella, a dominant bacterium in young people with stage Ⅲ periodontitis, related to the arachidonic acid metabolism pathway
Copyright © 2024 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved..
OBJECTS: As periodontitis progresses, the oral microbiome changes dynamically. The aim of this study is to evaluate the dominant bacteria of adults with stage III periodontitis and investigate potential pathways related to the dominant bacteria.
MATERIALS AND METHODS: 16S rRNA sequencing was carried out to detect the differences in the oral microbiome between adult with stage Ⅰ and stage Ⅲ periodontitis and find the dominant bacteria in each group. The inhibitor of the predominant pathway for stage Ⅲ periodontitis was used to investigate the role of the dominant bacteria in periodontitis in vivo and in vitro.
RESULTS: There was no significant difference in the α-diversity between the two groups. The results of β-diversity showed that the samples were divided into different groups according to the stage of periodontitis. The dominant bacteria in youths with stage Ⅲ periodontitis was Prevotella and may be related to the arachidonic acid metabolism pathway. Administration of SKF-86002 suppressed the expression of inflammation mediators in vivo and vitro.
CONCLUSIONS: Prevotella was the one dominant bacteria in young people with stage Ⅲ periodontitis and was related to the arachidonic acid metabolism pathway.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Microbes and infection - (2024) vom: 27. Feb., Seite 105316 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ye, Qin [VerfasserIn] |
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| Links: |
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| Themen: |
16S rRNA sequencing |
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| Anmerkungen: |
Date Revised 08.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.micinf.2024.105316 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369130707 |
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| 520 | |a Copyright © 2024 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a OBJECTS: As periodontitis progresses, the oral microbiome changes dynamically. The aim of this study is to evaluate the dominant bacteria of adults with stage III periodontitis and investigate potential pathways related to the dominant bacteria | ||
| 520 | |a MATERIALS AND METHODS: 16S rRNA sequencing was carried out to detect the differences in the oral microbiome between adult with stage Ⅰ and stage Ⅲ periodontitis and find the dominant bacteria in each group. The inhibitor of the predominant pathway for stage Ⅲ periodontitis was used to investigate the role of the dominant bacteria in periodontitis in vivo and in vitro | ||
| 520 | |a RESULTS: There was no significant difference in the α-diversity between the two groups. The results of β-diversity showed that the samples were divided into different groups according to the stage of periodontitis. The dominant bacteria in youths with stage Ⅲ periodontitis was Prevotella and may be related to the arachidonic acid metabolism pathway. Administration of SKF-86002 suppressed the expression of inflammation mediators in vivo and vitro | ||
| 520 | |a CONCLUSIONS: Prevotella was the one dominant bacteria in young people with stage Ⅲ periodontitis and was related to the arachidonic acid metabolism pathway | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 16S rRNA sequencing | |
| 650 | 4 | |a Arachidonic acid metabolism | |
| 650 | 4 | |a Periodontitis | |
| 650 | 4 | |a Prevotella | |
| 700 | 1 | |a Zhao, Yaqiong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Ouyang, Zeyue |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Xiaolin |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Ningxin |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Yunzhi |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Yue |e verfasserin |4 aut | |
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