Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice
Copyright © 2024 Elsevier Masson SAS. All rights reserved..
The modification based on natural products is a practical way to find anti-inflammatory drugs. In this study, 26 osthole derivatives were synthesized, and their anti-inflammatory properties were evaluated. The preliminary activity study revealed that most osthole derivatives could effectively inhibit inflammatory cytokines IL-6 secretion in LPS stimulated mouse macrophages J774A.1. Compound 7m exhibited the most effective anti-inflammatory activity (RAW264.7 IL-6 IC50: 4.57 μM, 32 times more active than osthole) in vitro with no significant influence on cell proliferation. Additionally, the mechanistic analysis demonstrated that compound 7m could block MAPK signal transduction by inhibiting the phosphorylation of JNK and p38, thereby inhibiting the release of inflammatory cytokines. Moreover, in vivo functional investigations revealed that 7m could substantially reduce DSS-induced ulcerative colitis and LPS-induced acute lung injury, with good therapeutic effects. The pharmacokinetics and acute toxicity experiments proved the safety and reliability of 7min vivo. Overall, Compound 7m could further be studied as potential anti-inflammatory candidate.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:268 |
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| Enthalten in: |
European journal of medicinal chemistry - 268(2024) vom: 15. März, Seite 116252 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhou, Ying [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 18.03.2024 Date Revised 18.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejmech.2024.116252 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369126033 |
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| 245 | 1 | 0 | |a Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a The modification based on natural products is a practical way to find anti-inflammatory drugs. In this study, 26 osthole derivatives were synthesized, and their anti-inflammatory properties were evaluated. The preliminary activity study revealed that most osthole derivatives could effectively inhibit inflammatory cytokines IL-6 secretion in LPS stimulated mouse macrophages J774A.1. Compound 7m exhibited the most effective anti-inflammatory activity (RAW264.7 IL-6 IC50: 4.57 μM, 32 times more active than osthole) in vitro with no significant influence on cell proliferation. Additionally, the mechanistic analysis demonstrated that compound 7m could block MAPK signal transduction by inhibiting the phosphorylation of JNK and p38, thereby inhibiting the release of inflammatory cytokines. Moreover, in vivo functional investigations revealed that 7m could substantially reduce DSS-induced ulcerative colitis and LPS-induced acute lung injury, with good therapeutic effects. The pharmacokinetics and acute toxicity experiments proved the safety and reliability of 7min vivo. Overall, Compound 7m could further be studied as potential anti-inflammatory candidate | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute lung injury | |
| 650 | 4 | |a Anti-inflammation | |
| 650 | 4 | |a IL-6 | |
| 650 | 4 | |a MAPK pathway | |
| 650 | 4 | |a Osthole derivatives | |
| 650 | 4 | |a Ulcerative colitis | |
| 650 | 7 | |a Lipopolysaccharides |2 NLM | |
| 650 | 7 | |a osthol |2 NLM | |
| 650 | 7 | |a XH1TI1759C |2 NLM | |
| 650 | 7 | |a Interleukin-6 |2 NLM | |
| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 650 | 7 | |a NF-kappa B |2 NLM | |
| 650 | 7 | |a Coumarins |2 NLM | |
| 700 | 1 | |a Du, Zhiteng |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Qianqian |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Mi |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zhichao |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Chenhui |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiaobo |e verfasserin |4 aut | |
| 700 | 1 | |a Zou, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Zhiwei |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Pan |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Won-Jea |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Young-Chang |e verfasserin |4 aut | |
| 700 | 1 | |a Chattipakorn, Nipon |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Guang |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Qidong |e verfasserin |4 aut | |
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