Cerebrospinal fluid drain infection caused by pandrug-resistant Staphylococcus epidermidis successfully treated with ceftaroline in combination with fosfomycin and vancomycin
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved..
External ventricular drain-related cerebrospinal fluid infection represents a fearsome complication of neurosurgical interventions. Although vancomycin represents the standard of care for methicillin-resistant CoNS healthcare-associated ventriculitis, resistance phenomena have been described. We reported a case of a persistent external ventricular fluid drain infection after device removal by pandrug-resistant Staphylococcus epidermidis successfully treated with intravenous ceftaroline in combination with fosfomycin and vancomycin. No evidence regarding pandrug-resistant S. epidermidis therapy currently exists to our knowledge. In this case, the S. epidermidis phenotype emerged during the therapy course, possibly due to initial device retention, biofilm formation and the host immune impaired response. Despite being poorly studied in vivo, ceftaroline may be considered an option when other alternatives are unavailable, thanks to its described activity against CoNS in vitro. This case extends the experience with ceftaroline for central nervous system infections suggesting it could also be used in high antimicrobial resistance settings for immunocompromised people.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:109 |
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| Enthalten in: |
Diagnostic microbiology and infectious disease - 109(2024), 1 vom: 30. März, Seite 116205 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Magrini, Eugenia [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 22.03.2024 Date Revised 22.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.diagmicrobio.2024.116205 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a External ventricular drain-related cerebrospinal fluid infection represents a fearsome complication of neurosurgical interventions. Although vancomycin represents the standard of care for methicillin-resistant CoNS healthcare-associated ventriculitis, resistance phenomena have been described. We reported a case of a persistent external ventricular fluid drain infection after device removal by pandrug-resistant Staphylococcus epidermidis successfully treated with intravenous ceftaroline in combination with fosfomycin and vancomycin. No evidence regarding pandrug-resistant S. epidermidis therapy currently exists to our knowledge. In this case, the S. epidermidis phenotype emerged during the therapy course, possibly due to initial device retention, biofilm formation and the host immune impaired response. Despite being poorly studied in vivo, ceftaroline may be considered an option when other alternatives are unavailable, thanks to its described activity against CoNS in vitro. This case extends the experience with ceftaroline for central nervous system infections suggesting it could also be used in high antimicrobial resistance settings for immunocompromised people | ||
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| 700 | 1 | |a Rando, Emanuele |e verfasserin |4 aut | |
| 700 | 1 | |a Del Giacomo, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Matteini, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Leanza, Gabriele Maria |e verfasserin |4 aut | |
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| 700 | 1 | |a Carbone, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Maiuro, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Dusina, Alex |e verfasserin |4 aut | |
| 700 | 1 | |a Cingolani, Antonella |e verfasserin |4 aut | |
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