Growth hormone treatment in children with short stature : impact of the diagnosis on parents
© 2024 Walter de Gruyter GmbH, Berlin/Boston..
OBJECTIVES: This prospective multicenter study aimed (1) to examine changes in parent-reported health-related quality of life (HRQOL) of children with short stature and the effects of the children's condition on parents themselves within the first year of human growth hormone (hGH) treatment and (2) to predict effects on parents based on main and interaction effects of children's HRQOL and increase in height.
METHODS: A total of 110 parents of children aged 4-18 years, diagnosed with idiopathic growth hormone deficiency, small for gestational age, or idiopathic short stature, were recruited from 11 participating German pediatric endocrinologists and asked to fill out the short stature-specific Quality of Life in Short Stature Youth (QoLISSY) Questionnaire before hGH treatment was initiated and one year later.
RESULTS: Negative effects of the children's short stature on the parents decrease over time, independent of diagnosis and treatment status. Furthermore, treatment status and height increase moderated the links between children's improved HRQOL as perceived by their parents and decreased caregiving burden.
CONCLUSIONS: Based on the children's improved HRQOL and the parent's decrease in caregiving burden, patient-reported outcomes that consider parental and child's perspectives should be considered when deciding on hGH treatment for children.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Journal of pediatric endocrinology & metabolism : JPEM - 37(2024), 4 vom: 25. Apr., Seite 326-335 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Witt, Stefanie [VerfasserIn] |
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| Links: |
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| Themen: |
12629-01-5 |
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| Anmerkungen: |
Date Completed 11.04.2024 Date Revised 13.04.2024 published: Electronic-Print Citation Status MEDLINE |
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| doi: |
10.1515/jpem-2023-0420 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369112350 |
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| 500 | |a Date Revised 13.04.2024 | ||
| 500 | |a published: Electronic-Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024 Walter de Gruyter GmbH, Berlin/Boston. | ||
| 520 | |a OBJECTIVES: This prospective multicenter study aimed (1) to examine changes in parent-reported health-related quality of life (HRQOL) of children with short stature and the effects of the children's condition on parents themselves within the first year of human growth hormone (hGH) treatment and (2) to predict effects on parents based on main and interaction effects of children's HRQOL and increase in height | ||
| 520 | |a METHODS: A total of 110 parents of children aged 4-18 years, diagnosed with idiopathic growth hormone deficiency, small for gestational age, or idiopathic short stature, were recruited from 11 participating German pediatric endocrinologists and asked to fill out the short stature-specific Quality of Life in Short Stature Youth (QoLISSY) Questionnaire before hGH treatment was initiated and one year later | ||
| 520 | |a RESULTS: Negative effects of the children's short stature on the parents decrease over time, independent of diagnosis and treatment status. Furthermore, treatment status and height increase moderated the links between children's improved HRQOL as perceived by their parents and decreased caregiving burden | ||
| 520 | |a CONCLUSIONS: Based on the children's improved HRQOL and the parent's decrease in caregiving burden, patient-reported outcomes that consider parental and child's perspectives should be considered when deciding on hGH treatment for children | ||
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a human growth hormone treatment | |
| 650 | 4 | |a parental burden | |
| 650 | 4 | |a short-statured children | |
| 650 | 7 | |a Human Growth Hormone |2 NLM | |
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| 700 | 1 | |a Bullinger, Monika |e verfasserin |4 aut | |
| 700 | 1 | |a Dörr, Helmuth-Günther |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Neuza |e verfasserin |4 aut | |
| 700 | 1 | |a Quitmann, Julia Hannah |e verfasserin |4 aut | |
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