Airway tree caliber heterogeneity and airflow obstruction among older adults
INTRODUCTION: Smaller mean airway tree caliber is associated with airflow obstruction and chronic obstructive pulmonary disease (COPD). We investigated whether airway tree caliber heterogeneity was associated with airflow obstruction and COPD.
METHODS: Two community-based cohorts (MESA Lung, CanCOLD) and a longitudinal case-control study of COPD (SPIROMICS) performed spirometry and computed tomography measurements of airway lumen diameters at standard anatomic locations and total lung volume. Percent-predicted airway lumen diameters were calculated using sex-specific reference equations accounting for age, height and lung volume. The association of airway tree caliber heterogeneity, quantified as the standard deviation (SD) of percent-predicted airway lumen diameters, with baseline forced expired volume in 1-second (FEV1), FEV1/forced vital capacity (FEV1/FVC) and COPD, as well as longitudinal spirometry, were assessed using regression models adjusted for age, sex, height, race-ethnicity, and mean airway tree caliber.
RESULTS: Among 2,505 MESA Lung participants (mean±SD age: 69±9 years; 53% female, mean airway tree caliber: 99±10% predicted, airway tree caliber heterogeneity: 14±5%; median follow-up: 6.1 years), participants in the highest quartile of airway tree caliber heterogeneity exhibited lower FEV1 (adjusted mean difference: -125 ml, 95%CI:-171,-79), lower FEV1/FVC (adjusted mean difference: -0.01, 95%CI:-0.02,-0.01), and higher odds of COPD (adjusted OR 1.42, 95%CI:1.01-2.02) when compared with the lowest quartile, whereas longitudinal changes in FEV1 and FEV1/FVC did not differ significantly. Observations in CanCOLD and SPIROMICS were consistent.
CONCLUSION: Among older adults, airway tree caliber heterogeneity was associated with airflow obstruction and COPD at baseline but was not associated with longitudinal changes in spirometry.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Journal of applied physiology (Bethesda, Md. : 1985) - (2024) vom: 29. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vameghestahbanati, Motahareh [VerfasserIn] |
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| Links: |
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| Themen: |
Airflow obstruction |
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| Anmerkungen: |
Date Revised 29.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1152/japplphysiol.00694.2022 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369105974 |
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| 100 | 1 | |a Vameghestahbanati, Motahareh |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Airway tree caliber heterogeneity and airflow obstruction among older adults |
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| 500 | |a Date Revised 29.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a INTRODUCTION: Smaller mean airway tree caliber is associated with airflow obstruction and chronic obstructive pulmonary disease (COPD). We investigated whether airway tree caliber heterogeneity was associated with airflow obstruction and COPD | ||
| 520 | |a METHODS: Two community-based cohorts (MESA Lung, CanCOLD) and a longitudinal case-control study of COPD (SPIROMICS) performed spirometry and computed tomography measurements of airway lumen diameters at standard anatomic locations and total lung volume. Percent-predicted airway lumen diameters were calculated using sex-specific reference equations accounting for age, height and lung volume. The association of airway tree caliber heterogeneity, quantified as the standard deviation (SD) of percent-predicted airway lumen diameters, with baseline forced expired volume in 1-second (FEV1), FEV1/forced vital capacity (FEV1/FVC) and COPD, as well as longitudinal spirometry, were assessed using regression models adjusted for age, sex, height, race-ethnicity, and mean airway tree caliber | ||
| 520 | |a RESULTS: Among 2,505 MESA Lung participants (mean±SD age: 69±9 years; 53% female, mean airway tree caliber: 99±10% predicted, airway tree caliber heterogeneity: 14±5%; median follow-up: 6.1 years), participants in the highest quartile of airway tree caliber heterogeneity exhibited lower FEV1 (adjusted mean difference: -125 ml, 95%CI:-171,-79), lower FEV1/FVC (adjusted mean difference: -0.01, 95%CI:-0.02,-0.01), and higher odds of COPD (adjusted OR 1.42, 95%CI:1.01-2.02) when compared with the lowest quartile, whereas longitudinal changes in FEV1 and FEV1/FVC did not differ significantly. Observations in CanCOLD and SPIROMICS were consistent | ||
| 520 | |a CONCLUSION: Among older adults, airway tree caliber heterogeneity was associated with airflow obstruction and COPD at baseline but was not associated with longitudinal changes in spirometry | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a airflow obstruction | |
| 650 | 4 | |a airway tree caliber heterogeneity | |
| 650 | 4 | |a chronic obstructive pulmonary disease | |
| 650 | 4 | |a computed tomography | |
| 700 | 1 | |a Kingdom, Leina |e verfasserin |4 aut | |
| 700 | 1 | |a Hoffman, Eric A |e verfasserin |4 aut | |
| 700 | 1 | |a Kirby, Miranda |e verfasserin |4 aut | |
| 700 | 1 | |a Allen, Norrina B |e verfasserin |4 aut | |
| 700 | 1 | |a Angelini, Elsa |e verfasserin |4 aut | |
| 700 | 1 | |a Bertoni, Alain |e verfasserin |4 aut | |
| 700 | 1 | |a Hamid, Qutayba |e verfasserin |4 aut | |
| 700 | 1 | |a Hogg, James C |e verfasserin |4 aut | |
| 700 | 1 | |a Jacobs, David R |c Jr |e verfasserin |4 aut | |
| 700 | 1 | |a Laine, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Maltais, François |e verfasserin |4 aut | |
| 700 | 1 | |a Michos, Erin D |e verfasserin |4 aut | |
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| 700 | 1 | |a Wysoczanksi, Artur |e verfasserin |4 aut | |
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