LDCT screening results among eligible and ineligible screening candidates in preventive health check-ups population : a real world study in West China
© 2024. The Author(s)..
To compare the LDCT screening results between eligible and ineligible screening candidates in preventive health check-ups population. Using a real-world LDCT screening results among people who took yearly health check-up in health management center of West China Hospital between 2006 and 2017. Objects were classified according to the China National Lung Cancer Screening Guideline with Low-dose Computed Tomography (2018 version) eligibility criteria. Descriptive analysis were performed between eligible and ineligible screening candidates. The proportion of ineligible screening candidates was 64.13% (10,259), and among them there were 4005 (39.04%) subjects with positive screenings, 80 cases had a surgical lung biopsy. Pathology results from lung biopsy revealed 154 cancers (true-positive) and 26 benign results (false-positive), the surgical false-positive biopsy rate was 4.17%, and ineligible group (7.69%) was higher than eligible group (2.47%), P < 0.05. Further, in ineligible screening candidates, the proportion of current smokers was higher among males compared to females (53.85% vs. 4.88%, P < 0.05). Of the 69 lung cancer patients detected in ineligible screening candidates, lung adenocarcinoma accounts for a high proportion of lung cancers both in male (75.00%) and female (85.00%). The proportion of ineligible screening candidates and the surgical false-positive biopsy rate in ineligible candidates were both high in health check-ups population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Scientific reports - 14(2024), 1 vom: 28. Feb., Seite 4848 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bao, Ting [VerfasserIn] |
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| Links: |
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| Themen: |
False-positive biopsy |
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| Anmerkungen: |
Date Completed 01.03.2024 Date Revised 02.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-024-55475-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369084470 |
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| 520 | |a To compare the LDCT screening results between eligible and ineligible screening candidates in preventive health check-ups population. Using a real-world LDCT screening results among people who took yearly health check-up in health management center of West China Hospital between 2006 and 2017. Objects were classified according to the China National Lung Cancer Screening Guideline with Low-dose Computed Tomography (2018 version) eligibility criteria. Descriptive analysis were performed between eligible and ineligible screening candidates. The proportion of ineligible screening candidates was 64.13% (10,259), and among them there were 4005 (39.04%) subjects with positive screenings, 80 cases had a surgical lung biopsy. Pathology results from lung biopsy revealed 154 cancers (true-positive) and 26 benign results (false-positive), the surgical false-positive biopsy rate was 4.17%, and ineligible group (7.69%) was higher than eligible group (2.47%), P < 0.05. Further, in ineligible screening candidates, the proportion of current smokers was higher among males compared to females (53.85% vs. 4.88%, P < 0.05). Of the 69 lung cancer patients detected in ineligible screening candidates, lung adenocarcinoma accounts for a high proportion of lung cancers both in male (75.00%) and female (85.00%). The proportion of ineligible screening candidates and the surgical false-positive biopsy rate in ineligible candidates were both high in health check-ups population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a False-positive biopsy | |
| 650 | 4 | |a Ineligible screening candidates | |
| 650 | 4 | |a Low-dose spiral CT | |
| 650 | 4 | |a Lung cancer screening | |
| 700 | 1 | |a Liu, Bingqing |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ruicen |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zhenzhen |e verfasserin |4 aut | |
| 700 | 1 | |a Ji, Guiyi |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Youjuan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Hanwei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Weimin |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Wenxia |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Huairong |e verfasserin |4 aut | |
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