Onosma glomeratum Y. L. Liu polysaccharide alleviates LPS-induced pulmonary inflammation via NF-κB signal pathway
Copyright © 2024 Elsevier B.V. All rights reserved..
As a traditional Chinese medicinal and edible homologous plant, Onosma glomeratum Y. L. Liu has been used for treating lung diseases in Tibet. In this study, a pectin polysaccharide, OGY-LLPA, with a molecular weight of 62,184 Da, was isolated and characterized by GC-MS and NMR analysis. It mainly consists of galacturonic acid (GalA), galactose (Gal), rhamnose (Rha), and arabinose (Ara), with a linear main chain of galacturonic acid (homogalacturonan, HG) inserted by part of rhamnose galacturonic acid (rhamnogalacturonan, RG), attaching with arabinogalactan (AG) branches at RG-I. Both in the LPS-induced A549 cell model and LPS-induced pneumonia mouse model, OGY-LLPA demonstrated strong anti-inflammatory effects, even comparable to DEX, indicating its potential as an anti-pneumonia candidate agent. Moreover, low-dose OGY-LLPA alleviated LPS-induced pulmonary inflammation by inhibiting the NF-κB signaling pathway. Overall, these findings could not only contribute to the utilization of Onosma glomeratum Y. L. Liu., but also provides a theoretical basis for the treatment of inflammation-related diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:263 |
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| Enthalten in: |
International journal of biological macromolecules - 263(2024), Pt 2 vom: 28. März, Seite 130452 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yang, Qian [VerfasserIn] |
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| Links: |
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| Themen: |
4JK6RN80GF |
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| Anmerkungen: |
Date Completed 27.03.2024 Date Revised 27.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijbiomac.2024.130452 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM36907677X |
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| 245 | 1 | 0 | |a Onosma glomeratum Y. L. Liu polysaccharide alleviates LPS-induced pulmonary inflammation via NF-κB signal pathway |
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| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a As a traditional Chinese medicinal and edible homologous plant, Onosma glomeratum Y. L. Liu has been used for treating lung diseases in Tibet. In this study, a pectin polysaccharide, OGY-LLPA, with a molecular weight of 62,184 Da, was isolated and characterized by GC-MS and NMR analysis. It mainly consists of galacturonic acid (GalA), galactose (Gal), rhamnose (Rha), and arabinose (Ara), with a linear main chain of galacturonic acid (homogalacturonan, HG) inserted by part of rhamnose galacturonic acid (rhamnogalacturonan, RG), attaching with arabinogalactan (AG) branches at RG-I. Both in the LPS-induced A549 cell model and LPS-induced pneumonia mouse model, OGY-LLPA demonstrated strong anti-inflammatory effects, even comparable to DEX, indicating its potential as an anti-pneumonia candidate agent. Moreover, low-dose OGY-LLPA alleviated LPS-induced pulmonary inflammation by inhibiting the NF-κB signaling pathway. Overall, these findings could not only contribute to the utilization of Onosma glomeratum Y. L. Liu., but also provides a theoretical basis for the treatment of inflammation-related diseases | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Onosma glomeratum Y. L. Liu | |
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| 700 | 1 | |a Shen, Xuelian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Junxi |e verfasserin |4 aut | |
| 700 | 1 | |a Er-Bu, Aga |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Xiaoxia |e verfasserin |4 aut | |
| 700 | 1 | |a He, Changliang |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Lizi |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Funeng |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Haohuan |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Huaqiao |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Yuping |e verfasserin |4 aut | |
| 700 | 1 | |a Lv, Cheng |e verfasserin |4 aut | |
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