Gut microbiota and cognitive performance : A bidirectional two-sample Mendelian randomization
Copyright © 2024 Elsevier B.V. All rights reserved..
PURPOSE: Previous studies have suggested a potential association between gut microbiota and neurological and psychiatric disorders. However, the causal relationship between gut microbiota and cognitive performance remains uncertain.
METHODS: A two-sample Mendelian randomization (MR) study used SNPs linked to gut microbiota (n = 18,340) and cognitive performance (n = 257,841) from recent GWAS data. Inverse-variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode were employed. Heterogeneity was assessed via Cochran's Q test for IVW. Results were shown with funnel plots. Outliers were detected through leave-one-out method. MR-PRESSO and MR-Egger intercept tests were conducted to address horizontal pleiotropy influence.
LIMITATIONS: Limited to European populations, generic level, and potential confounding factors.
RESULTS: IVW analysis revealed detrimental effects on cognitive perfmance associated with the presence of genus Blautia (P = 0.013, 0.966[0.940-0.993]), Catenibacterium (P = 0.035, 0.977[0.956-0.998]), Oxalobacter (P = 0.043, 0.979[0.960-0.999]). Roseburia (P < 0.001, 0.935[0.906-0.965]), in particular, remained strongly negatively associated with cognitive performance after Bonferroni correction. Conversely, families including Bacteroidaceae (P = 0.043, 1.040[1.001-1.081]), Rikenellaceae (P = 0.047, 1.026[1.000-1.053]), along with genera including Paraprevotella (P = 0.044, 1.020[1.001-1.039]), Ruminococcus torques group (P = 0.016, 1.062[1.011-1.115]), Bacteroides (P = 0.043, 1.040[1.001-1.081]), Dialister (P = 0.027, 1.039[1.004-1.074]), Paraprevotella (P = 0.044, 1.020[1.001-1.039]) and Ruminococcaceae UCG003 (P = 0.007, 1.040[1.011-1.070]) had a protective effect on cognitive performance.
CONCLUSIONS: Our results suggest that interventions targeting specific gut microbiota may offer a promising avenue for improving cognitive function in diseased populations. The practical application of these findings has the potential to enhance cognitive performance, thereby improving overall quality of life.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:353 |
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Enthalten in: |
Journal of affective disorders - 353(2024) vom: 15. März, Seite 38-47 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Wang, Qian [VerfasserIn] |
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Links: |
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Themen: |
Causal correlation |
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Anmerkungen: |
Date Completed 19.03.2024 Date Revised 19.03.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.jad.2024.02.083 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM369076303 |
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100 | 1 | |a Wang, Qian |e verfasserin |4 aut | |
245 | 1 | 0 | |a Gut microbiota and cognitive performance |b A bidirectional two-sample Mendelian randomization |
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500 | |a Date Completed 19.03.2024 | ||
500 | |a Date Revised 19.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
520 | |a PURPOSE: Previous studies have suggested a potential association between gut microbiota and neurological and psychiatric disorders. However, the causal relationship between gut microbiota and cognitive performance remains uncertain | ||
520 | |a METHODS: A two-sample Mendelian randomization (MR) study used SNPs linked to gut microbiota (n = 18,340) and cognitive performance (n = 257,841) from recent GWAS data. Inverse-variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode were employed. Heterogeneity was assessed via Cochran's Q test for IVW. Results were shown with funnel plots. Outliers were detected through leave-one-out method. MR-PRESSO and MR-Egger intercept tests were conducted to address horizontal pleiotropy influence | ||
520 | |a LIMITATIONS: Limited to European populations, generic level, and potential confounding factors | ||
520 | |a RESULTS: IVW analysis revealed detrimental effects on cognitive perfmance associated with the presence of genus Blautia (P = 0.013, 0.966[0.940-0.993]), Catenibacterium (P = 0.035, 0.977[0.956-0.998]), Oxalobacter (P = 0.043, 0.979[0.960-0.999]). Roseburia (P < 0.001, 0.935[0.906-0.965]), in particular, remained strongly negatively associated with cognitive performance after Bonferroni correction. Conversely, families including Bacteroidaceae (P = 0.043, 1.040[1.001-1.081]), Rikenellaceae (P = 0.047, 1.026[1.000-1.053]), along with genera including Paraprevotella (P = 0.044, 1.020[1.001-1.039]), Ruminococcus torques group (P = 0.016, 1.062[1.011-1.115]), Bacteroides (P = 0.043, 1.040[1.001-1.081]), Dialister (P = 0.027, 1.039[1.004-1.074]), Paraprevotella (P = 0.044, 1.020[1.001-1.039]) and Ruminococcaceae UCG003 (P = 0.007, 1.040[1.011-1.070]) had a protective effect on cognitive performance | ||
520 | |a CONCLUSIONS: Our results suggest that interventions targeting specific gut microbiota may offer a promising avenue for improving cognitive function in diseased populations. The practical application of these findings has the potential to enhance cognitive performance, thereby improving overall quality of life | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Causal correlation | |
650 | 4 | |a Cognitive performance | |
650 | 4 | |a Gut microbiota | |
650 | 4 | |a Large scale analysis | |
650 | 4 | |a Mendelian randomization | |
700 | 1 | |a Song, Yu-Xiang |e verfasserin |4 aut | |
700 | 1 | |a Wu, Xiao-Dong |e verfasserin |4 aut | |
700 | 1 | |a Luo, Yun-Gen |e verfasserin |4 aut | |
700 | 1 | |a Miao, Ran |e verfasserin |4 aut | |
700 | 1 | |a Yu, Xiao-Meng |e verfasserin |4 aut | |
700 | 1 | |a Guo, Xu |e verfasserin |4 aut | |
700 | 1 | |a Wu, De-Zhen |e verfasserin |4 aut | |
700 | 1 | |a Bao, Rui |e verfasserin |4 aut | |
700 | 1 | |a Mi, Wei-Dong |e verfasserin |4 aut | |
700 | 1 | |a Cao, Jiang-Bei |e verfasserin |4 aut | |
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