New clerodane diterpenoids from Callicarpa pseudorubella and their antitumor proliferative activity
Copyright © 2024. Published by Elsevier B.V..
Six previously undescribed clerodane diterpenes, cardorubellas A-F (1-6), along with seven known ones (7-13), were isolated from the aerial parts of Callicarpa pseudorubella. Their chemical structures were established by analysis of 1D and 2D NMR, HR-ESI-MS, X-ray diffraction, and electronic circular dichroism (ECD) data. Notably, cardorubella B (2) represented the first examples of naturally occurring succinic anhydride-containing clerodane diterpenes derivatives. The anti-proliferative activities of these compounds were assessed. Remarkably, compound 2 exhibited comparable inhibitory activity against HEL cell lines, surpassing the positive control with an IC50 value of 14.01 ± 0.77 μM, compared to 17.02 ± 4.70 μM for 5-fluorouracil.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:174 |
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| Enthalten in: |
Fitoterapia - 174(2024) vom: 28. März, Seite 105878 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Xing [VerfasserIn] |
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| Links: |
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| Themen: |
Callicarpa pseudorubella |
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| Anmerkungen: |
Date Completed 25.03.2024 Date Revised 25.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.fitote.2024.105878 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a New clerodane diterpenoids from Callicarpa pseudorubella and their antitumor proliferative activity |
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| 520 | |a Copyright © 2024. Published by Elsevier B.V. | ||
| 520 | |a Six previously undescribed clerodane diterpenes, cardorubellas A-F (1-6), along with seven known ones (7-13), were isolated from the aerial parts of Callicarpa pseudorubella. Their chemical structures were established by analysis of 1D and 2D NMR, HR-ESI-MS, X-ray diffraction, and electronic circular dichroism (ECD) data. Notably, cardorubella B (2) represented the first examples of naturally occurring succinic anhydride-containing clerodane diterpenes derivatives. The anti-proliferative activities of these compounds were assessed. Remarkably, compound 2 exhibited comparable inhibitory activity against HEL cell lines, surpassing the positive control with an IC50 value of 14.01 ± 0.77 μM, compared to 17.02 ± 4.70 μM for 5-fluorouracil | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Callicarpa pseudorubella | |
| 650 | 4 | |a Clerodane diterpenes | |
| 650 | 4 | |a Electronic circular dichroism | |
| 650 | 4 | |a Human erythroleukemia (HEL) cells | |
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| 650 | 7 | |a Diterpenes |2 NLM | |
| 700 | 1 | |a Zheng, Zhaopeng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Huan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Hanfei |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jinyu |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Lou, Huayong |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Weidong |e verfasserin |4 aut | |
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