Preventive effects of hesperidin in an experimental model ofs acute lung inflammation
Copyright © 2024 Elsevier B.V. All rights reserved..
In this study, we hypothesized that long-term administration of hesperidin can modulate the inflammatory response and oxidative stress in animals submitted to mechanical ventilation (MV). Twenty-five C57BL/6 male mice were divided into 5 groups: control, MV, animals receiving hesperidin in three doses 10, 25 and 50 mg/kg. The animals received the doses of hesperidin for 30 days via orogastric gavage, and at the end of the period the animals were submitted to MV. In animals submitted to MV, increased lymphocyte, neutrophil and monocyte/macrophage cell counts were observed in the blood and airways. Associated to this, MV promoted an increase in inflammatory cytokine levels such as CCL2, IL-12 and TNFα. The daily administration of hesperidin in the three doses prevented the effects caused by MV, which was observed by a lower influx of inflammatory cells into the airways, a reduction in inflammatory markers and less oxidative damage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:323 |
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| Enthalten in: |
Respiratory physiology & neurobiology - 323(2024) vom: 28. März, Seite 104240 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Souza, Ana Beatriz Farias [VerfasserIn] |
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| Links: |
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| Themen: |
Acute lung injury |
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| Anmerkungen: |
Date Completed 18.03.2024 Date Revised 18.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.resp.2024.104240 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369074831 |
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| 245 | 1 | 0 | |a Preventive effects of hesperidin in an experimental model ofs acute lung inflammation |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a In this study, we hypothesized that long-term administration of hesperidin can modulate the inflammatory response and oxidative stress in animals submitted to mechanical ventilation (MV). Twenty-five C57BL/6 male mice were divided into 5 groups: control, MV, animals receiving hesperidin in three doses 10, 25 and 50 mg/kg. The animals received the doses of hesperidin for 30 days via orogastric gavage, and at the end of the period the animals were submitted to MV. In animals submitted to MV, increased lymphocyte, neutrophil and monocyte/macrophage cell counts were observed in the blood and airways. Associated to this, MV promoted an increase in inflammatory cytokine levels such as CCL2, IL-12 and TNFα. The daily administration of hesperidin in the three doses prevented the effects caused by MV, which was observed by a lower influx of inflammatory cells into the airways, a reduction in inflammatory markers and less oxidative damage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute lung injury | |
| 650 | 4 | |a Flavonoids | |
| 650 | 4 | |a Hesperidin | |
| 650 | 4 | |a Mechanical ventilation | |
| 650 | 7 | |a Hesperidin |2 NLM | |
| 650 | 7 | |a E750O06Y6O |2 NLM | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 650 | 7 | |a Tumor Necrosis Factor-alpha |2 NLM | |
| 700 | 1 | |a de Matos, Natália Alves |e verfasserin |4 aut | |
| 700 | 1 | |a Castro, Thalles de Freitas |e verfasserin |4 aut | |
| 700 | 1 | |a Costa, Guilherme de Paula |e verfasserin |4 aut | |
| 700 | 1 | |a Talvani, André |e verfasserin |4 aut | |
| 700 | 1 | |a Nagato, Akinori Cardozo |e verfasserin |4 aut | |
| 700 | 1 | |a de Menezes, Rodrigo Cunha Alvim |e verfasserin |4 aut | |
| 700 | 1 | |a Bezerra, Frank Silva |e verfasserin |4 aut | |
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