The acute effects of cannabis, with and without cannabidiol, on attentional bias to cannabis related cues : a randomised, double-blind, placebo-controlled, cross-over study
© 2024. The Author(s)..
RATIONALE: Attentional bias to drug-related stimuli is hypothesised to contribute towards addiction. However, the acute effects of Δ9-tetrahydrocannabinol (THC) on attentional bias to cannabis cues, the differential response in adults and adolescents, and the moderating effect of cannabidiol (CBD) are unknown.
OBJECTIVES: Our study investigated (1) the acute effects of vaporised cannabis on attentional bias to cannabis-related images in adults and adolescents and (2) the moderating influences of age and CBD.
METHODS: We conducted a randomised, double-blind, placebo-controlled, cross-over study where three weight-adjusted vaporised cannabis preparations: 'THC' (8 mg THC for a 75-kg person), 'THC + CBD' (8 mg THC and 24 mg CBD for a 75-kg person) and PLA (matched placebo). Cannabis was administered on 3 separate days to 48 participants, who used cannabis 0.5-3 days/week: 24 adolescents (12 females, aged 16-17) and 24 adults (12 females, aged 26-29). Participants completed a visual probe task with cannabis cues. Our primary outcome was attentional bias to cannabis stimuli, measured using the differential reaction time to a cannabis vs. neutral probe, on 200-ms trials.
RESULTS: In contrast to hypotheses, attention was directed away from cannabis cues on placebo, and there was a main effect of the drug (F(2,92) = 3.865, p = 0.024, η2p = 0.077), indicating THC administration eliminated this bias. There was no significant impact of CBD nor an age-by-drug interaction.
CONCLUSIONS: Acute THC intoxication eliminated attentional bias away from cannabis cues. There was no evidence of differential response in adolescents compared to adults and no evidence that a moderate vaporised dose of CBD altered the impact of cannabis on attentional bias.
TRIAL REGISTRATION: This study was listed with the US National Library of Medicine and registered on ClinicalTrials.gov, URL: Do Adolescents and Adults Differ in Their Acute Response to Cannabis?-Full Text View-ClinicalTrials.gov, registration number: NCT04851392.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Psychopharmacology - (2024) vom: 28. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hall, Daniel [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 28.02.2024 published: Print-Electronic ClinicalTrials.gov: NCT04851392 Citation Status Publisher |
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| doi: |
10.1007/s00213-024-06543-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369061462 |
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| 100 | 1 | |a Hall, Daniel |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The acute effects of cannabis, with and without cannabidiol, on attentional bias to cannabis related cues |b a randomised, double-blind, placebo-controlled, cross-over study |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Revised 28.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT04851392 | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a RATIONALE: Attentional bias to drug-related stimuli is hypothesised to contribute towards addiction. However, the acute effects of Δ9-tetrahydrocannabinol (THC) on attentional bias to cannabis cues, the differential response in adults and adolescents, and the moderating effect of cannabidiol (CBD) are unknown | ||
| 520 | |a OBJECTIVES: Our study investigated (1) the acute effects of vaporised cannabis on attentional bias to cannabis-related images in adults and adolescents and (2) the moderating influences of age and CBD | ||
| 520 | |a METHODS: We conducted a randomised, double-blind, placebo-controlled, cross-over study where three weight-adjusted vaporised cannabis preparations: 'THC' (8 mg THC for a 75-kg person), 'THC + CBD' (8 mg THC and 24 mg CBD for a 75-kg person) and PLA (matched placebo). Cannabis was administered on 3 separate days to 48 participants, who used cannabis 0.5-3 days/week: 24 adolescents (12 females, aged 16-17) and 24 adults (12 females, aged 26-29). Participants completed a visual probe task with cannabis cues. Our primary outcome was attentional bias to cannabis stimuli, measured using the differential reaction time to a cannabis vs. neutral probe, on 200-ms trials | ||
| 520 | |a RESULTS: In contrast to hypotheses, attention was directed away from cannabis cues on placebo, and there was a main effect of the drug (F(2,92) = 3.865, p = 0.024, η2p = 0.077), indicating THC administration eliminated this bias. There was no significant impact of CBD nor an age-by-drug interaction | ||
| 520 | |a CONCLUSIONS: Acute THC intoxication eliminated attentional bias away from cannabis cues. There was no evidence of differential response in adolescents compared to adults and no evidence that a moderate vaporised dose of CBD altered the impact of cannabis on attentional bias | ||
| 520 | |a TRIAL REGISTRATION: This study was listed with the US National Library of Medicine and registered on ClinicalTrials.gov, URL: Do Adolescents and Adults Differ in Their Acute Response to Cannabis?-Full Text View-ClinicalTrials.gov, registration number: NCT04851392 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Adolescence | |
| 650 | 4 | |a Attentional bias | |
| 650 | 4 | |a CBD | |
| 650 | 4 | |a Cannabis | |
| 650 | 4 | |a THC | |
| 700 | 1 | |a Lawn, Will |e verfasserin |4 aut | |
| 700 | 1 | |a Ofori, Shelan |e verfasserin |4 aut | |
| 700 | 1 | |a Trinci, Katie |e verfasserin |4 aut | |
| 700 | 1 | |a Borissova, Anya |e verfasserin |4 aut | |
| 700 | 1 | |a Mokrysz, Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Petrilli, Kat |e verfasserin |4 aut | |
| 700 | 1 | |a Bloomfield, Michael A P |e verfasserin |4 aut | |
| 700 | 1 | |a Wall, Matthew B |e verfasserin |4 aut | |
| 700 | 1 | |a Freeman, Tom P |e verfasserin |4 aut | |
| 700 | 1 | |a Curran, H Valerie |e verfasserin |4 aut | |
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