Clinicopathological predictors of postoperative long-term myasthenic status in resected thymoma with myasthenia gravis
© 2024. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd..
PURPOSE: Surgical patients with thymoma and myasthenia gravis (MG) must have their MG status and oncological outcomes critically monitored. We aimed to identify clinicopathological predictors of the postoperative MG status.
METHODS: We conducted a retrospective review of 40 consecutive surgical patients with MG-related thymomas between 2002 and 2020. The quantitative myasthenia gravis score (QMGS) and Myasthenia Gravis Foundation of America post-intervention status (MGFA-PIS) were used to evaluate postoperative MG status.
RESULTS: All patients underwent extended total thymectomy. The most common WHO type was type B2 (32%), while 65% of patients had type B1-B3 and 35% had type A-AB thymomas. Eleven patients (28%) achieved controlled MG status in MGFA-PIS 6 months after surgery. This controlled status was observed more frequently in type A-AB than in B1-B3 (57% vs. 12%, p = 0.007). In a multivariate analysis, WHO type (A-AB or B1-B3) was an independent predictor of worsening episodes of MG based on the QMGS (Type B1-B3, hazard ratio: 3.23, 95% confidence interval: 1.12-9.25). At the last follow-up, 23 patients (58%) achieved controlled MG status. The 5-year overall survival rate of all patients was 93.7%.
CONCLUSION: The WHO type of thymoma is an informative predictor of postoperative MG status in patients with MG-related thymoma.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Surgery today - (2024) vom: 28. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Suzuki, Takahiro [VerfasserIn] |
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| Anmerkungen: |
Date Revised 28.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1007/s00595-024-02806-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369060652 |
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| 245 | 1 | 0 | |a Clinicopathological predictors of postoperative long-term myasthenic status in resected thymoma with myasthenia gravis |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2024. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd. | ||
| 520 | |a PURPOSE: Surgical patients with thymoma and myasthenia gravis (MG) must have their MG status and oncological outcomes critically monitored. We aimed to identify clinicopathological predictors of the postoperative MG status | ||
| 520 | |a METHODS: We conducted a retrospective review of 40 consecutive surgical patients with MG-related thymomas between 2002 and 2020. The quantitative myasthenia gravis score (QMGS) and Myasthenia Gravis Foundation of America post-intervention status (MGFA-PIS) were used to evaluate postoperative MG status | ||
| 520 | |a RESULTS: All patients underwent extended total thymectomy. The most common WHO type was type B2 (32%), while 65% of patients had type B1-B3 and 35% had type A-AB thymomas. Eleven patients (28%) achieved controlled MG status in MGFA-PIS 6 months after surgery. This controlled status was observed more frequently in type A-AB than in B1-B3 (57% vs. 12%, p = 0.007). In a multivariate analysis, WHO type (A-AB or B1-B3) was an independent predictor of worsening episodes of MG based on the QMGS (Type B1-B3, hazard ratio: 3.23, 95% confidence interval: 1.12-9.25). At the last follow-up, 23 patients (58%) achieved controlled MG status. The 5-year overall survival rate of all patients was 93.7% | ||
| 520 | |a CONCLUSION: The WHO type of thymoma is an informative predictor of postoperative MG status in patients with MG-related thymoma | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Myasthenia gravis | |
| 650 | 4 | |a Thymectomy | |
| 650 | 4 | |a Thymoma | |
| 700 | 1 | |a Hishida, Tomoyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Shigeaki |e verfasserin |4 aut | |
| 700 | 1 | |a Okubo, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Masai, Kyohei |e verfasserin |4 aut | |
| 700 | 1 | |a Kaseda, Kaoru |e verfasserin |4 aut | |
| 700 | 1 | |a Asakura, Keisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Emoto, Katsura |e verfasserin |4 aut | |
| 700 | 1 | |a Asamura, Hisao |e verfasserin |4 aut | |
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