The Tehran longitudinal family-based cardiometabolic cohort study sheds new light on dyslipidemia transmission patterns
© 2024. The Author(s)..
Dyslipidemia, as a metabolic risk factor, with the strongest and most heritable independent cause of cardiovascular diseases worldwide. We investigated the familial transmission patterns of dyslipidemia through a longitudinal family-based cohort, the Tehran Cardiometabolic Genetic Study (TCGS) in Iran. We enrolled 18,729 individuals (45% were males) aged > 18 years (mean: 38.15 (15.82)) and observed them over five 3-year follow-up periods. We evaluated the serum concentrations of total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol with the first measurement among longitudinal measures and the average measurements (AM) of the five periods. Heritability analysis was conducted using a mixed-effect framework with likelihood-based and Bayesian approaches. The periodic prevalence and heritability of dyslipidemia were estimated to be 65.7 and 42%, respectively. The likelihood of an individual having at least one dyslipidemic parent reveals an OR = 6.94 (CI 5.28-9.30) compared to those who do not have dyslipidemic parents. The most considerable intraclass correlation of family members was for the same-sex siblings, with ICC ~ 25.5%. For serum concentrations, heritability ranged from 33.64 to 60.95%. Taken together, these findings demonstrate that familial transmission of dyslipidemia in the Tehran population is strong, especially within the same-gender siblings. According to previous reports, the heritability of dyslipidemia in this population is considerably higher than the global average.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
---|---|
Enthalten in: |
Scientific reports - 14(2024), 1 vom: 27. Feb., Seite 4739 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Akbarzadeh, Mahdi [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Completed 29.02.2024 Date Revised 01.03.2024 published: Electronic Citation Status MEDLINE |
---|
doi: |
10.1038/s41598-024-53504-3 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM369035437 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM369035437 | ||
003 | DE-627 | ||
005 | 20240301232715.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240229s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1038/s41598-024-53504-3 |2 doi | |
028 | 5 | 2 | |a pubmed24n1313.xml |
035 | |a (DE-627)NLM369035437 | ||
035 | |a (NLM)38413617 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Akbarzadeh, Mahdi |e verfasserin |4 aut | |
245 | 1 | 4 | |a The Tehran longitudinal family-based cardiometabolic cohort study sheds new light on dyslipidemia transmission patterns |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 29.02.2024 | ||
500 | |a Date Revised 01.03.2024 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2024. The Author(s). | ||
520 | |a Dyslipidemia, as a metabolic risk factor, with the strongest and most heritable independent cause of cardiovascular diseases worldwide. We investigated the familial transmission patterns of dyslipidemia through a longitudinal family-based cohort, the Tehran Cardiometabolic Genetic Study (TCGS) in Iran. We enrolled 18,729 individuals (45% were males) aged > 18 years (mean: 38.15 (15.82)) and observed them over five 3-year follow-up periods. We evaluated the serum concentrations of total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol with the first measurement among longitudinal measures and the average measurements (AM) of the five periods. Heritability analysis was conducted using a mixed-effect framework with likelihood-based and Bayesian approaches. The periodic prevalence and heritability of dyslipidemia were estimated to be 65.7 and 42%, respectively. The likelihood of an individual having at least one dyslipidemic parent reveals an OR = 6.94 (CI 5.28-9.30) compared to those who do not have dyslipidemic parents. The most considerable intraclass correlation of family members was for the same-sex siblings, with ICC ~ 25.5%. For serum concentrations, heritability ranged from 33.64 to 60.95%. Taken together, these findings demonstrate that familial transmission of dyslipidemia in the Tehran population is strong, especially within the same-gender siblings. According to previous reports, the heritability of dyslipidemia in this population is considerably higher than the global average | ||
650 | 4 | |a Journal Article | |
650 | 7 | |a Triglycerides |2 NLM | |
650 | 7 | |a Cholesterol, HDL |2 NLM | |
700 | 1 | |a Riahi, Parisa |e verfasserin |4 aut | |
700 | 1 | |a Saeidian, Amir Hossein |e verfasserin |4 aut | |
700 | 1 | |a Zarkesh, Maryam |e verfasserin |4 aut | |
700 | 1 | |a Masjoudi, Sajedeh |e verfasserin |4 aut | |
700 | 1 | |a Asgarian, Sara |e verfasserin |4 aut | |
700 | 1 | |a Guity, Kamran |e verfasserin |4 aut | |
700 | 1 | |a Moheimani, Hamed |e verfasserin |4 aut | |
700 | 1 | |a Masoudi, Homayoon |e verfasserin |4 aut | |
700 | 1 | |a Roudbar, Mahmoud Amiri |e verfasserin |4 aut | |
700 | 1 | |a Khalili, Davood |e verfasserin |4 aut | |
700 | 1 | |a Hosseinpanah, Farhad |e verfasserin |4 aut | |
700 | 1 | |a Barzin, Maryam |e verfasserin |4 aut | |
700 | 1 | |a Hogan, Carolyn T |e verfasserin |4 aut | |
700 | 1 | |a Hakonarson, Hakon |e verfasserin |4 aut | |
700 | 1 | |a Hedayati, Mehdi |e verfasserin |4 aut | |
700 | 1 | |a Daneshpour, Maryam S |e verfasserin |4 aut | |
700 | 1 | |a Azizi, Fereidoun |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Scientific reports |d 2011 |g 14(2024), 1 vom: 27. Feb., Seite 4739 |w (DE-627)NLM215703936 |x 2045-2322 |7 nnns |
773 | 1 | 8 | |g volume:14 |g year:2024 |g number:1 |g day:27 |g month:02 |g pages:4739 |
856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41598-024-53504-3 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 14 |j 2024 |e 1 |b 27 |c 02 |h 4739 |