Cardiac Tuberculosis : A Case Series from Ethiopia, Italy, and Uganda and a Literature Review
Extrapulmonary tuberculosis (TB) is estimated to account for up to 20% of active cases of TB disease, but its prevalence is difficult to ascertain because of the difficulty of diagnosis. Involvement of the heart is uncommon, with constrictive pericarditis being the most common cardiac manifestation. Diagnostic research for cardiac disease is frequently lacking, resulting in a high mortality rate. In addition to direct cardiac involvement, instances of cardiac events during antitubercular therapy are described. This case series describes five cases of TB affecting the heart (cardiac TB) from Italy and high-burden, low-income countries (Ethiopia and Uganda), including a case of Loeffler syndrome manifesting as myocarditis in a patient receiving antitubercular therapy. Our study emphasizes how cardiac TB, rare but important in high-burden areas, is a leading cause of pericardial effusion or pericarditis. Timely diagnosis and a comprehensive approach, including imaging and microbiological tools, are crucial. Implementing high-sensitivity methods and investigating alternative samples, such as detection of tuberculosis lipoarabinomannan or use of the GeneXpert assay with stool, is recommended in TB control programs.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:110 |
---|---|
Enthalten in: |
The American journal of tropical medicine and hygiene - 110(2024), 4 vom: 03. Apr., Seite 795-804 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Cotugno, Sergio [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Completed 05.04.2024 Date Revised 06.04.2024 published: Electronic-Print Citation Status MEDLINE |
---|
doi: |
10.4269/ajtmh.23-0505 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM369024699 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM369024699 | ||
003 | DE-627 | ||
005 | 20240406232212.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240229s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.4269/ajtmh.23-0505 |2 doi | |
028 | 5 | 2 | |a pubmed24n1367.xml |
035 | |a (DE-627)NLM369024699 | ||
035 | |a (NLM)38412542 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Cotugno, Sergio |e verfasserin |4 aut | |
245 | 1 | 0 | |a Cardiac Tuberculosis |b A Case Series from Ethiopia, Italy, and Uganda and a Literature Review |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 05.04.2024 | ||
500 | |a Date Revised 06.04.2024 | ||
500 | |a published: Electronic-Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Extrapulmonary tuberculosis (TB) is estimated to account for up to 20% of active cases of TB disease, but its prevalence is difficult to ascertain because of the difficulty of diagnosis. Involvement of the heart is uncommon, with constrictive pericarditis being the most common cardiac manifestation. Diagnostic research for cardiac disease is frequently lacking, resulting in a high mortality rate. In addition to direct cardiac involvement, instances of cardiac events during antitubercular therapy are described. This case series describes five cases of TB affecting the heart (cardiac TB) from Italy and high-burden, low-income countries (Ethiopia and Uganda), including a case of Loeffler syndrome manifesting as myocarditis in a patient receiving antitubercular therapy. Our study emphasizes how cardiac TB, rare but important in high-burden areas, is a leading cause of pericardial effusion or pericarditis. Timely diagnosis and a comprehensive approach, including imaging and microbiological tools, are crucial. Implementing high-sensitivity methods and investigating alternative samples, such as detection of tuberculosis lipoarabinomannan or use of the GeneXpert assay with stool, is recommended in TB control programs | ||
650 | 4 | |a Review | |
650 | 4 | |a Case Reports | |
650 | 4 | |a Journal Article | |
650 | 7 | |a Antitubercular Agents |2 NLM | |
700 | 1 | |a Guido, Giacomo |e verfasserin |4 aut | |
700 | 1 | |a Manco Cesari, Giorgia |e verfasserin |4 aut | |
700 | 1 | |a Ictho, Jerry |e verfasserin |4 aut | |
700 | 1 | |a Lochoro, Peter |e verfasserin |4 aut | |
700 | 1 | |a Amone, James |e verfasserin |4 aut | |
700 | 1 | |a Segala, Francesco Vladimiro |e verfasserin |4 aut | |
700 | 1 | |a De Vita, Elda |e verfasserin |4 aut | |
700 | 1 | |a Lattanzio, Rossana |e verfasserin |4 aut | |
700 | 1 | |a Okori, Samuel |e verfasserin |4 aut | |
700 | 1 | |a De Iaco, Giuseppina |e verfasserin |4 aut | |
700 | 1 | |a Girma, Adisu |e verfasserin |4 aut | |
700 | 1 | |a Sura, Abata |e verfasserin |4 aut | |
700 | 1 | |a Hessebo, Eriballo Tariku |e verfasserin |4 aut | |
700 | 1 | |a Balsemin, Franco |e verfasserin |4 aut | |
700 | 1 | |a Putoto, Giovanni |e verfasserin |4 aut | |
700 | 1 | |a Ronga, Luigi |e verfasserin |4 aut | |
700 | 1 | |a Manenti, Fabio |e verfasserin |4 aut | |
700 | 1 | |a Facci, Enzo |e verfasserin |4 aut | |
700 | 1 | |a Saracino, Annalisa |e verfasserin |4 aut | |
700 | 1 | |a Di Gennaro, Francesco |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t The American journal of tropical medicine and hygiene |d 1945 |g 110(2024), 4 vom: 03. Apr., Seite 795-804 |w (DE-627)NLM000012513 |x 1476-1645 |7 nnns |
773 | 1 | 8 | |g volume:110 |g year:2024 |g number:4 |g day:03 |g month:04 |g pages:795-804 |
856 | 4 | 0 | |u http://dx.doi.org/10.4269/ajtmh.23-0505 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 110 |j 2024 |e 4 |b 03 |c 04 |h 795-804 |