Amino acid formula induces microbiota dysbiosis and depressive-like behavior in mice
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved..
Amino acid formula (AAF) is increasingly consumed in infants with cow's milk protein allergy; however, the long-term influences on health are less described. In this study, we established a mouse model by subjecting neonatal mice to an amino acid diet (AAD) to mimic the feeding regimen of infants on AAF. Surprisingly, AAD-fed mice exhibited dysbiotic microbiota and increased neuronal activity in both the intestine and brain, as well as gastrointestinal peristalsis disorders and depressive-like behavior. Furthermore, fecal microbiota transplantation from AAD-fed mice or AAF-fed infants to recipient mice led to elevated neuronal activations and exacerbated depressive-like behaviors compared to that from normal chow-fed mice or cow's-milk-formula-fed infants, respectively. Our findings highlight the necessity to avoid the excessive use of AAF, which may influence the neuronal development and mental health of children.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Cell reports - 43(2024), 3 vom: 26. März, Seite 113817 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hu, Ji [VerfasserIn] |
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| Links: |
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| Themen: |
Amino Acids |
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| Anmerkungen: |
Date Completed 01.04.2024 Date Revised 01.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.celrep.2024.113817 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM369020456 |
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| 520 | |a Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Amino acid formula (AAF) is increasingly consumed in infants with cow's milk protein allergy; however, the long-term influences on health are less described. In this study, we established a mouse model by subjecting neonatal mice to an amino acid diet (AAD) to mimic the feeding regimen of infants on AAF. Surprisingly, AAD-fed mice exhibited dysbiotic microbiota and increased neuronal activity in both the intestine and brain, as well as gastrointestinal peristalsis disorders and depressive-like behavior. Furthermore, fecal microbiota transplantation from AAD-fed mice or AAF-fed infants to recipient mice led to elevated neuronal activations and exacerbated depressive-like behaviors compared to that from normal chow-fed mice or cow's-milk-formula-fed infants, respectively. Our findings highlight the necessity to avoid the excessive use of AAF, which may influence the neuronal development and mental health of children | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CP: Microbiology | |
| 650 | 4 | |a CP: Neuroscience | |
| 650 | 4 | |a amino acid formula | |
| 650 | 4 | |a depression | |
| 650 | 4 | |a microbiota | |
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| 700 | 1 | |a He, Kaixin |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yifei |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Chuan |e verfasserin |4 aut | |
| 700 | 1 | |a Dou, Yiping |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Hao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Guorong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jingyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Niu, Chaoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Bi, Guoqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Lan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Shu |e verfasserin |4 aut | |
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