Association of dietary flavonoid intakes with prevalence of chronic respiratory diseases in adults
© 2024. The Author(s)..
BACKGROUND AND AIMS: Flavonoids are a class of secondary plant metabolites that have been shown to have multiple health benefits, including antioxidant and anti-inflammatory. This study was to explore the association between dietary flavonoid consumption and the prevalence of chronic respiratory diseases (CRDs) in adults.
METHODS AND RESULTS: The six main types of flavonoids, including isoflavones, anthocyanidins, flavan-3-ols, flavanones, flavones, and flavonols, were obtained from the National Health and Nutrition Examination Survey (NHANES) 2007-2010 and 2017-2018 by the two 24-h recall interviews. The prevalence of CRDs, including asthma, emphysema, and chronic bronchitis, was determined through a self-administered questionnaire. The analysis included 15,753 participants aged 18 years or older who had completed a diet history interview. After adjustment for potential confounders, the inverse link was found with total flavonoids, anthocyanidins, flavanones, and flavones, with an OR (95%CI) of 0.86 (0.75-0.98), 0.84 (0.72-0.97), 0.80(0.69-0.92), and 0.85(0.73-0.98) for the highest group compared to the lowest group. WQS regression revealed that the mixture of flavonoids was negatively linked with the prevalence of CRDs (OR = 0.88 [0.82-0.95], P < 0.01), and the largest effect was mainly from flavanones (weight = 0.41). In addition, we found that flavonoid intake was negatively linked with inflammatory markers, and systemic inflammation significantly mediated the associations of flavonoids with CRDs, with a mediation rate of 12.64% for CRP (P < 0.01).
CONCLUSION: Higher flavonoid intake was related with a lower prevalence of CRDs in adults, and this relationship may be mediated through systemic inflammation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Journal of translational medicine - 22(2024), 1 vom: 26. Feb., Seite 205 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wu, Runmiao [VerfasserIn] |
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| Links: |
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| Themen: |
Anthocyanidins |
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| Anmerkungen: |
Date Completed 28.02.2024 Date Revised 29.02.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12967-024-04949-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM368989968 |
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| 520 | |a © 2024. The Author(s). | ||
| 520 | |a BACKGROUND AND AIMS: Flavonoids are a class of secondary plant metabolites that have been shown to have multiple health benefits, including antioxidant and anti-inflammatory. This study was to explore the association between dietary flavonoid consumption and the prevalence of chronic respiratory diseases (CRDs) in adults | ||
| 520 | |a METHODS AND RESULTS: The six main types of flavonoids, including isoflavones, anthocyanidins, flavan-3-ols, flavanones, flavones, and flavonols, were obtained from the National Health and Nutrition Examination Survey (NHANES) 2007-2010 and 2017-2018 by the two 24-h recall interviews. The prevalence of CRDs, including asthma, emphysema, and chronic bronchitis, was determined through a self-administered questionnaire. The analysis included 15,753 participants aged 18 years or older who had completed a diet history interview. After adjustment for potential confounders, the inverse link was found with total flavonoids, anthocyanidins, flavanones, and flavones, with an OR (95%CI) of 0.86 (0.75-0.98), 0.84 (0.72-0.97), 0.80(0.69-0.92), and 0.85(0.73-0.98) for the highest group compared to the lowest group. WQS regression revealed that the mixture of flavonoids was negatively linked with the prevalence of CRDs (OR = 0.88 [0.82-0.95], P < 0.01), and the largest effect was mainly from flavanones (weight = 0.41). In addition, we found that flavonoid intake was negatively linked with inflammatory markers, and systemic inflammation significantly mediated the associations of flavonoids with CRDs, with a mediation rate of 12.64% for CRP (P < 0.01) | ||
| 520 | |a CONCLUSION: Higher flavonoid intake was related with a lower prevalence of CRDs in adults, and this relationship may be mediated through systemic inflammation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anthocyanidins | |
| 650 | 4 | |a Chronic respiratory diseases | |
| 650 | 4 | |a Flavan-3-ols | |
| 650 | 4 | |a Flavanones | |
| 650 | 4 | |a Flavones | |
| 650 | 4 | |a Flavonoids | |
| 650 | 4 | |a Flavonols | |
| 650 | 4 | |a Isoflavones | |
| 650 | 7 | |a Flavonoids |2 NLM | |
| 650 | 7 | |a Anthocyanins |2 NLM | |
| 650 | 7 | |a Flavones |2 NLM | |
| 650 | 7 | |a Flavanones |2 NLM | |
| 700 | 1 | |a Zhu, Xu |e verfasserin |4 aut | |
| 700 | 1 | |a Guan, Gongchang |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Qianwei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Xing, Yujie |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Jingsha |e verfasserin |4 aut | |
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