Functional interaction of Clock genes and bone morphogenetic proteins in the adrenal cortex
Copyright © 2023. Published by Elsevier Inc..
The bone morphogenetic protein (BMP) system in the adrenal cortex plays modulatory roles in the control of adrenocortical steroidogenesis. BMP-6 enhances aldosterone production by modulating angiotensin (Ang) II-mitogen-activated protein kinase (MAPK) signaling, whereas activin regulates the adrenocorticotropin (ACTH)-cAMP cascade in adrenocortical cells. A peripheral clock system in the adrenal cortex was discovered and it has been shown to have functional roles in the adjustment of adrenocortical steroidogenesis by interacting with the BMP system. It was found that follistatin, a binding protein of activin, increased Clock mRNA levels, indicating an endogenous function of activin in the regulation of Clock mRNA expression. Elucidation of the interrelationships among the circadian clock system, the BMP system and adrenocortical steroidogenesis regulated by the hypothalamic-pituitary-adrenal (HPA) axis would lead to an understanding of the pathophysiology of adrenal disorders and metabolic disorders and the establishment of better medical treatment from the viewpoint of pharmacokinetics.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:124 |
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| Enthalten in: |
Vitamins and hormones - 124(2024) vom: 25., Seite 429-447 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Soejima, Yoshiaki [VerfasserIn] |
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| Links: |
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| Themen: |
104625-48-1 |
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| Anmerkungen: |
Date Completed 28.02.2024 Date Revised 28.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/bs.vh.2023.05.002 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368987663 |
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| 245 | 1 | 0 | |a Functional interaction of Clock genes and bone morphogenetic proteins in the adrenal cortex |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023. Published by Elsevier Inc. | ||
| 520 | |a The bone morphogenetic protein (BMP) system in the adrenal cortex plays modulatory roles in the control of adrenocortical steroidogenesis. BMP-6 enhances aldosterone production by modulating angiotensin (Ang) II-mitogen-activated protein kinase (MAPK) signaling, whereas activin regulates the adrenocorticotropin (ACTH)-cAMP cascade in adrenocortical cells. A peripheral clock system in the adrenal cortex was discovered and it has been shown to have functional roles in the adjustment of adrenocortical steroidogenesis by interacting with the BMP system. It was found that follistatin, a binding protein of activin, increased Clock mRNA levels, indicating an endogenous function of activin in the regulation of Clock mRNA expression. Elucidation of the interrelationships among the circadian clock system, the BMP system and adrenocortical steroidogenesis regulated by the hypothalamic-pituitary-adrenal (HPA) axis would lead to an understanding of the pathophysiology of adrenal disorders and metabolic disorders and the establishment of better medical treatment from the viewpoint of pharmacokinetics | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Activin | |
| 650 | 4 | |a Adrenal gland | |
| 650 | 4 | |a Bone morphogenetic protein (BMP) | |
| 650 | 4 | |a Clock | |
| 650 | 4 | |a Steroidogenesis | |
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| 650 | 7 | |a Aldosterone |2 NLM | |
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| 700 | 1 | |a Nakano, Yasuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Suyama, Atsuhito |e verfasserin |4 aut | |
| 700 | 1 | |a Iwata, Nahoko |e verfasserin |4 aut | |
| 700 | 1 | |a Otsuka, Fumio |e verfasserin |4 aut | |
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