Decreased immune response in undernourished rats after air pollution exposure
Copyright © 2024 Elsevier B.V. All rights reserved..
Children are highly vulnerable subpopulation to malnutrition and air pollution. We investigate, in a rat nutritional growth retardation (NGR) model, the impact of Residual Oil Fly Ash (ROFA) on the lung immune response using in vitro and ex vivo methods. In vitro: Alveolar macrophages (AM) were isolated from Control (C) and NGR animals, cultured and treated with ROFA (1-100 µg/ml) for 24 h. Ex vivo: C and NGR rats were intranasally instilled with ROFA (1 mg/kg BW) or PBS. 24 h post-exposure AM were isolated and cultured. ROFA-treatment increased superoxide anion production and TNFα secretion in C-AM in vitro, though for NGR-AM this response was lower. A similar pattern was observed for TNFα and IL-6 secretion in ex vivo experiments. Regarding the antioxidant response, although NGR-AM showed increased Nrf2, after ROFA instillation an attenuated activation was observed. To conclude, chronic undernutrition altered AM response to ROFA affecting immune responsiveness to air pollutants.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:107 |
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| Enthalten in: |
Environmental toxicology and pharmacology - 107(2024) vom: 24. Apr., Seite 104400 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kurtz, Melisa Lidia [VerfasserIn] |
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| Links: |
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| Themen: |
7440-44-0 |
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| Anmerkungen: |
Date Completed 16.04.2024 Date Revised 16.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.etap.2024.104400 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368986799 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 Elsevier B.V. All rights reserved. | ||
| 520 | |a Children are highly vulnerable subpopulation to malnutrition and air pollution. We investigate, in a rat nutritional growth retardation (NGR) model, the impact of Residual Oil Fly Ash (ROFA) on the lung immune response using in vitro and ex vivo methods. In vitro: Alveolar macrophages (AM) were isolated from Control (C) and NGR animals, cultured and treated with ROFA (1-100 µg/ml) for 24 h. Ex vivo: C and NGR rats were intranasally instilled with ROFA (1 mg/kg BW) or PBS. 24 h post-exposure AM were isolated and cultured. ROFA-treatment increased superoxide anion production and TNFα secretion in C-AM in vitro, though for NGR-AM this response was lower. A similar pattern was observed for TNFα and IL-6 secretion in ex vivo experiments. Regarding the antioxidant response, although NGR-AM showed increased Nrf2, after ROFA instillation an attenuated activation was observed. To conclude, chronic undernutrition altered AM response to ROFA affecting immune responsiveness to air pollutants | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Air pollution | |
| 650 | 4 | |a Alveolar Macrophages | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Malnutrition | |
| 650 | 4 | |a Oxidative Metabolism | |
| 650 | 4 | |a Particulate Matter | |
| 650 | 4 | |a ROFA | |
| 650 | 7 | |a Particulate Matter |2 NLM | |
| 650 | 7 | |a Tumor Necrosis Factor-alpha |2 NLM | |
| 650 | 7 | |a Air Pollutants |2 NLM | |
| 650 | 7 | |a Coal Ash |2 NLM | |
| 650 | 7 | |a Carbon |2 NLM | |
| 650 | 7 | |a 7440-44-0 |2 NLM | |
| 700 | 1 | |a Orona, Nadia Soledad |e verfasserin |4 aut | |
| 700 | 1 | |a Lezón, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Defosse, Verónica Cecilia |e verfasserin |4 aut | |
| 700 | 1 | |a Astort, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Maglione, Guillermo Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Boyer, Patricia Mónica |e verfasserin |4 aut | |
| 700 | 1 | |a Tasat, Deborah Ruth |e verfasserin |4 aut | |
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