Revisiting the evolution of Family B1 GPCRs and ligands : Insights from mollusca
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved..
Family B1 G protein-coupled receptors (GPCRs) are one of the most well studied neuropeptide receptor families since they play a central role in many biological processes including endocrine, gastrointestinal, cardiovascular and reproduction in animals. The genes for these receptors emerged from a common ancestral gene in bilaterian genomes and evolved via gene/genome duplications and deletions in vertebrate and invertebrate genomes. Their existence and function have mostly been characterized in vertebrates and few studies exist in invertebrate species. Recently, an increased interest in molluscs, means a series of genomes have become available, and since they are less modified than insect and nematode genomes, they are ideal to explore the origin and evolution of neuropeptide gene families. This review provides an overview of Family B1 GPCRs and their peptide ligands and incorporates new data obtained from Mollusca genomes and taking a comparative approach challenges existing models on their origin and evolution.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:586 |
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Enthalten in: |
Molecular and cellular endocrinology - 586(2024) vom: 15. Apr., Seite 112192 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Cardoso, João C R [VerfasserIn] |
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Themen: |
Evolution |
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Anmerkungen: |
Date Completed 08.04.2024 Date Revised 08.04.2024 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.mce.2024.112192 |
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PPN (Katalog-ID): |
NLM368985636 |
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520 | |a Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. | ||
520 | |a Family B1 G protein-coupled receptors (GPCRs) are one of the most well studied neuropeptide receptor families since they play a central role in many biological processes including endocrine, gastrointestinal, cardiovascular and reproduction in animals. The genes for these receptors emerged from a common ancestral gene in bilaterian genomes and evolved via gene/genome duplications and deletions in vertebrate and invertebrate genomes. Their existence and function have mostly been characterized in vertebrates and few studies exist in invertebrate species. Recently, an increased interest in molluscs, means a series of genomes have become available, and since they are less modified than insect and nematode genomes, they are ideal to explore the origin and evolution of neuropeptide gene families. This review provides an overview of Family B1 GPCRs and their peptide ligands and incorporates new data obtained from Mollusca genomes and taking a comparative approach challenges existing models on their origin and evolution | ||
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700 | 1 | |a Peng, Maoxiao |e verfasserin |4 aut | |
700 | 1 | |a Power, Deborah M |e verfasserin |4 aut | |
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