Chitosan nanoparticles laden contact lenses for enzyme-triggered controlled delivery of timolol maleate : A promising strategy for managing glaucoma
© 2024. Controlled Release Society..
To improve drug bioavailability, eye drops can be replaced by drug-eluting contact lenses. However, issues of drug leaching from lenses during manufacture and storage, and sterilization, currently limit their commercial application. To address the issues, stimuli-(lysozyme)-sensitive chitosan nanoparticles were developed to provide controlled ocular drug delivery. Nanoparticles were prepared by ionic gelation and characterized by TEM, X-ray diffraction, DSC, and FTIR. In the flux study, conventional-soaked contact lenses (SM-TM-CL) showed high-burst release, while with direct drug-only laden contact lenses (DL-TM-CL) the drug was lost during extraction and sterilization, as well as having poor swelling and optical properties. The nanoparticle-laden contact lenses (TM-Cht-NPs) showed controlled release of timolol for 120 h in the presence of lysozyme, with acceptable opto-physical properties. In the shelf-life study, the TM-Cht-NPs contact lenses showed no leaching or alteration in the drug release pattern. In animal studies, the TM-NPs-CL lenses gave a high drug concentration in rabbit tear fluid (mean = 11.01 µg/mL for 56 h) and helped maintain a low intraocular pressure for 120 h. In conclusion, the chitosan nanoparticle-laden contact lenses demonstrated the potential application to treat glaucoma with acceptable opto-physical properties and addressed the issues of drug-leaching during sterilization and storage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Drug delivery and translational research - (2024) vom: 26. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Maulvi, Furqan A [VerfasserIn] |
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| Links: |
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| Themen: |
Chitosan nanoparticles |
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| Anmerkungen: |
Date Revised 26.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1007/s13346-024-01543-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368977404 |
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| 100 | 1 | |a Maulvi, Furqan A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chitosan nanoparticles laden contact lenses for enzyme-triggered controlled delivery of timolol maleate |b A promising strategy for managing glaucoma |
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| 520 | |a © 2024. Controlled Release Society. | ||
| 520 | |a To improve drug bioavailability, eye drops can be replaced by drug-eluting contact lenses. However, issues of drug leaching from lenses during manufacture and storage, and sterilization, currently limit their commercial application. To address the issues, stimuli-(lysozyme)-sensitive chitosan nanoparticles were developed to provide controlled ocular drug delivery. Nanoparticles were prepared by ionic gelation and characterized by TEM, X-ray diffraction, DSC, and FTIR. In the flux study, conventional-soaked contact lenses (SM-TM-CL) showed high-burst release, while with direct drug-only laden contact lenses (DL-TM-CL) the drug was lost during extraction and sterilization, as well as having poor swelling and optical properties. The nanoparticle-laden contact lenses (TM-Cht-NPs) showed controlled release of timolol for 120 h in the presence of lysozyme, with acceptable opto-physical properties. In the shelf-life study, the TM-Cht-NPs contact lenses showed no leaching or alteration in the drug release pattern. In animal studies, the TM-NPs-CL lenses gave a high drug concentration in rabbit tear fluid (mean = 11.01 µg/mL for 56 h) and helped maintain a low intraocular pressure for 120 h. In conclusion, the chitosan nanoparticle-laden contact lenses demonstrated the potential application to treat glaucoma with acceptable opto-physical properties and addressed the issues of drug-leaching during sterilization and storage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Chitosan nanoparticles | |
| 650 | 4 | |a Contact lens | |
| 650 | 4 | |a Controlled drug delivery | |
| 650 | 4 | |a Glaucoma | |
| 650 | 4 | |a Timolol maleate | |
| 700 | 1 | |a Patel, Ashmi R |e verfasserin |4 aut | |
| 700 | 1 | |a Shetty, Kiran H |e verfasserin |4 aut | |
| 700 | 1 | |a Desai, Ditixa T |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Dinesh O |e verfasserin |4 aut | |
| 700 | 1 | |a Willcox, Mark D P |e verfasserin |4 aut | |
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