Male spondyloarthritis patients and those with longer disease duration have less severe disc degeneration : propensity score-matched comparison

© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology..

Objective: Using whole spine sagittal T2 MRI, we aimed to compare the severity and prevalence of disc degeneration (DD) in axial SpA patients vs the general population and to determine any association between spinal inflammation, structural changes, mobility and DD among SpA patients.

Methods: Two prospectively collected cohorts of SpA patients (n = 411) and the general population (n = 2007) were recruited. Eventually, 967 participants from the populational cohort and 304 participants from the SpA cohort were analysed. Two hundred and nineteen matched pairs were generated by propensity score matching. Imaging parameters, including Pfirrmann grading, disc herniation, high-intensity zone, Schmorl's node, Modic change and anterior marrow change were studied and compared from C2/3 to L5/S1. DD was defined as Pfirrmann grade 4 or 5. Demographic factors, including age, sex and BMI, were collected. Multivariable linear regression was used to determine the association between spinal inflammation [Spondyloarthritis Research Consortium of Canada (SPARCC) spine MRI index], structural changes [modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS)] and mobility (BASMI) with lumbar Pfirrmann score.

Results: SpA patients had lower prevalence of DD (P < 0.001). The disease stage-stratified regression model showed that SPARCC spinal MRI index was associated with higher lumbar Pfirrmann scores in early disease (β = 0.196, P = 0.044), whereas mSASSS was associated with lower lumbar Pfirrmann scores in later disease (β = -0.138, P = 0.038). Males had higher mSASSS (P < 0.001) and lower odds of whole spine DD (odds ratio = 0.622, P = 0.028).

Conclusion: SpA patients had lower DD severity than the general population. Males had higher mSASSSs, and increased mSASSS at later disease was associated with less severe DD.

Medienart:	E-Artikel

Erscheinungsjahr:	2024
Erschienen:	2024

Enthalten in:	Zur Gesamtaufnahme - volume:8
Enthalten in:	Rheumatology advances in practice - 8(2024), 1 vom: 21., Seite rkae015

Sprache:	Englisch

Beteiligte Personen:	Cheung, Samuel Tin Yan [VerfasserIn] Tsang, Helen Hoi Lun [VerfasserIn] Cheung, Prudence Wing Hang [VerfasserIn] Cheung, Jason Pui Yin [VerfasserIn]

Links:	Volltext

Themen:	Disc degeneration Journal Article MRI Modified Stoke Ankylosing Spondylitis Spinal Score Spondyloarthritis Spondyloarthritis Research Consortium of Canada

Anmerkungen:	Date Revised 27.02.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE

doi:	10.1093/rap/rkae015

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	NLM36895045X