Predictors of outcome and symptomatic intracranial hemorrhage in acute basilar artery occlusions : Analysis of the PC-SEARCH thrombectomy registry
INTRODUCTION: Recent randomized controlled trials demonstrated superiority of mechanical thrombectomy compared to medical therapy in acute basilar artery occlusions, however, little data is available to guide clinicians in functional prognosis and risk stratification.
PATIENTS AND METHODS: Data from the retrospectively established PC-SEARCH Thrombectomy registry, which included patients with basilar artery occlusion from eight sites from January 2015 to December 2021, was interrogated. Outcomes were dichotomized into 90-day favorable (mRS ⩽ 3) and unfavorable (mRS > 3). Multivariate logistic regression analysis was performed with respect to the outcome groups and were adjusted for potential confounding baseline characteristics.
RESULTS: Four-hundred-forty-four patients were included in this analysis. Mean age was 66 [SD 15], with 56% male, and comprised of 76% Caucasian. Patients presented with an initial median NIHSS of 18 and 199 patients (44.8%) achieved favorable 90-day functional outcomes. Independent predictors of favorable outcomes included younger age, pc-ASPECTS > 8 (OR 2.30 p < 0.001), and TICI ⩾ 2b (OR 7.56 p < 0.001). Unfavorable outcomes were associated with increasing number of passes (OR 1.29 p = 0.004) and sICH (OR 4.19 p = 0.015). IA-tPA was an independent risk factor for sICH (OR 7.15 p = 0.002) without improving favorable functional outcomes.
CONCLUSION AND DISCUSSION: PC-ASPECTS > 8, successful recanalization (TICI ⩾ 2b), first-pass recanalization, and younger age are independent predictors of favorable 90-day functional outcome in thrombectomy treated patients with acute basilar artery occlusion. Conversely, sICH were independent predictors of unfavorable outcomes. IA-tPA and unsuccessful recanalization are independently associated with sICH.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
European stroke journal - (2024) vom: 25. Feb., Seite 23969873241234713 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mierzwa, Adam T [VerfasserIn] |
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| Anmerkungen: |
Date Revised 26.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1177/23969873241234713 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368938964 |
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| 041 | |a eng | ||
| 100 | 1 | |a Mierzwa, Adam T |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Predictors of outcome and symptomatic intracranial hemorrhage in acute basilar artery occlusions |b Analysis of the PC-SEARCH thrombectomy registry |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Revised 26.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a INTRODUCTION: Recent randomized controlled trials demonstrated superiority of mechanical thrombectomy compared to medical therapy in acute basilar artery occlusions, however, little data is available to guide clinicians in functional prognosis and risk stratification | ||
| 520 | |a PATIENTS AND METHODS: Data from the retrospectively established PC-SEARCH Thrombectomy registry, which included patients with basilar artery occlusion from eight sites from January 2015 to December 2021, was interrogated. Outcomes were dichotomized into 90-day favorable (mRS ⩽ 3) and unfavorable (mRS > 3). Multivariate logistic regression analysis was performed with respect to the outcome groups and were adjusted for potential confounding baseline characteristics | ||
| 520 | |a RESULTS: Four-hundred-forty-four patients were included in this analysis. Mean age was 66 [SD 15], with 56% male, and comprised of 76% Caucasian. Patients presented with an initial median NIHSS of 18 and 199 patients (44.8%) achieved favorable 90-day functional outcomes. Independent predictors of favorable outcomes included younger age, pc-ASPECTS > 8 (OR 2.30 p < 0.001), and TICI ⩾ 2b (OR 7.56 p < 0.001). Unfavorable outcomes were associated with increasing number of passes (OR 1.29 p = 0.004) and sICH (OR 4.19 p = 0.015). IA-tPA was an independent risk factor for sICH (OR 7.15 p = 0.002) without improving favorable functional outcomes | ||
| 520 | |a CONCLUSION AND DISCUSSION: PC-ASPECTS > 8, successful recanalization (TICI ⩾ 2b), first-pass recanalization, and younger age are independent predictors of favorable 90-day functional outcome in thrombectomy treated patients with acute basilar artery occlusion. Conversely, sICH were independent predictors of unfavorable outcomes. IA-tPA and unsuccessful recanalization are independently associated with sICH | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Stroke | |
| 650 | 4 | |a basilar artery | |
| 650 | 4 | |a thrombectomy | |
| 700 | 1 | |a Nelson, Ashley |e verfasserin |4 aut | |
| 700 | 1 | |a Kasab, Sami Al |e verfasserin |4 aut | |
| 700 | 1 | |a Ortega Gutierrez, Santiago |e verfasserin |4 aut | |
| 700 | 1 | |a Vivanco-Suarez, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Farooqui, Mudassir |e verfasserin |4 aut | |
| 700 | 1 | |a Jadhav, Ashutosh P |e verfasserin |4 aut | |
| 700 | 1 | |a Desai, Shashvat |e verfasserin |4 aut | |
| 700 | 1 | |a Toth, Gabor |e verfasserin |4 aut | |
| 700 | 1 | |a Alrohimi, Anas |e verfasserin |4 aut | |
| 700 | 1 | |a Nguyen, Thanh N |e verfasserin |4 aut | |
| 700 | 1 | |a Klein, Piers |e verfasserin |4 aut | |
| 700 | 1 | |a Abdalkader, Mohamad |e verfasserin |4 aut | |
| 700 | 1 | |a Salahuddin, Hisham |e verfasserin |4 aut | |
| 700 | 1 | |a Pandey, Aditya |e verfasserin |4 aut | |
| 700 | 1 | |a Wilseck, Zachary |e verfasserin |4 aut | |
| 700 | 1 | |a Koduri, Sravanthi |e verfasserin |4 aut | |
| 700 | 1 | |a Vora, Niraj |e verfasserin |4 aut | |
| 700 | 1 | |a Aladamat, Nameer |e verfasserin |4 aut | |
| 700 | 1 | |a Gharaibeh, Khaled |e verfasserin |4 aut | |
| 700 | 1 | |a Afreen, Ehad |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Hajala, Hisham |e verfasserin |4 aut | |
| 700 | 1 | |a Shawver, Julie |e verfasserin |4 aut | |
| 700 | 1 | |a Zaidi, Syed |e verfasserin |4 aut | |
| 700 | 1 | |a Jumaa, Mouhammad |e verfasserin |4 aut | |
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