Innate and adaptive immunity in acute myocarditis
Copyright © 2024 Elsevier B.V. All rights reserved..
Acute myocarditis is an acute inflammatory cardiomyopathy associated with cardiac damage triggered by a virus or a pathological immune activation. It may present with a wide range of clinical presentations, ranging from mild symptoms to severe forms like fulminant myocarditis, characterized by hemodynamic compromise and cardiogenic shock. The immune system plays a central role in the pathogenesis of myocarditis. In fact, while its function is primarily protective, aberrant responses can be detrimental. In this context, both innate and adaptive immunity play pivotal roles; notably, the innate system offers a non-specific and immediate defense, while the adaptive provides specialized protection with immunological memory. However, dysregulation in these systems can misidentify cardiac tissue, triggering autoimmune reactions and possibly leading to significant cardiac tissue damage. This review highlights the importance of innate and adaptive immune responses in the progression and treatment of acute myocarditis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:404 |
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| Enthalten in: |
International journal of cardiology - 404(2024) vom: 01. Apr., Seite 131901 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Golino, Michele [VerfasserIn] |
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| Links: |
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| Themen: |
Adaptive immunity |
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| Anmerkungen: |
Date Completed 08.04.2024 Date Revised 08.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2024.131901 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368931781 |
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| 520 | |a Acute myocarditis is an acute inflammatory cardiomyopathy associated with cardiac damage triggered by a virus or a pathological immune activation. It may present with a wide range of clinical presentations, ranging from mild symptoms to severe forms like fulminant myocarditis, characterized by hemodynamic compromise and cardiogenic shock. The immune system plays a central role in the pathogenesis of myocarditis. In fact, while its function is primarily protective, aberrant responses can be detrimental. In this context, both innate and adaptive immunity play pivotal roles; notably, the innate system offers a non-specific and immediate defense, while the adaptive provides specialized protection with immunological memory. However, dysregulation in these systems can misidentify cardiac tissue, triggering autoimmune reactions and possibly leading to significant cardiac tissue damage. This review highlights the importance of innate and adaptive immune responses in the progression and treatment of acute myocarditis | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Adaptive immunity | |
| 650 | 4 | |a Inflammasome | |
| 650 | 4 | |a Innate immunity | |
| 650 | 4 | |a Interleukin-1 | |
| 650 | 4 | |a Myocarditis | |
| 700 | 1 | |a Harding, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Del Buono, Marco Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Fanti, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Mohiddin, Saidi |e verfasserin |4 aut | |
| 700 | 1 | |a Toldo, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Smyth, James |e verfasserin |4 aut | |
| 700 | 1 | |a Sanna, Tommaso |e verfasserin |4 aut | |
| 700 | 1 | |a Marelli-Berg, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Abbate, Antonio |e verfasserin |4 aut | |
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