New reference limits for cardiac troponin T and N-terminal b-type natriuretic propeptide in elders
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved..
BACKGROUND AND AIMS: Our aim was to define reference limits for cardiac troponin T (cTnT) and N-terminal pro B-type natriuretic peptide (proBNP) that would better reflect their concentrations in older people. In addition, the incidence of acute myocardial infarctions (AMIs) was studied using these reference limits in an older population with and without previous heart diseases.
MATERIALS AND METHODS: A population-based study with a ten-year follow-up. The reference population was formed by 763 individuals aged over 64 years, with no diagnoses of heart or kidney diseases.
RESULTS: There was a significant increase in cTnT and proBNP concentrations with age. The 99 % reference limits for cTnT were 25 ng/L, 28 ng/l, 38 ng/l, and 71 ng/l for men in five-year-intervals starting from 64 to 69 years to 80 years and older, and 18 ng/L, 22 ng/l, 26 ng/l, and 52 ng/L for women, respectively. The 97.5 % reference limits for proBNP were 272 ng/L, 287 ng/l, 373 ng/l and 686 ng/L for men, and 341 ng/L, 377 ng/l, 471 ng/l, and 794 ng/L for women, respectively. Elevated proBNP was statistically significantly associated with future AMIs in subjects with and without a previous heart disease.
CONCLUSIONS: Age-specific reference limits for cTnT and proBNP are needed to better evaluate cardiac symptoms.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:556 |
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| Enthalten in: |
Clinica chimica acta; international journal of clinical chemistry - 556(2024) vom: 15. März, Seite 117844 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Heikkilä, Elisa [VerfasserIn] |
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| Links: |
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| Themen: |
114471-18-0 |
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| Anmerkungen: |
Date Completed 18.03.2024 Date Revised 18.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cca.2024.117844 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368931269 |
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| 245 | 1 | 0 | |a New reference limits for cardiac troponin T and N-terminal b-type natriuretic propeptide in elders |
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| 500 | |a Date Revised 18.03.2024 | ||
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| 520 | |a Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND AND AIMS: Our aim was to define reference limits for cardiac troponin T (cTnT) and N-terminal pro B-type natriuretic peptide (proBNP) that would better reflect their concentrations in older people. In addition, the incidence of acute myocardial infarctions (AMIs) was studied using these reference limits in an older population with and without previous heart diseases | ||
| 520 | |a MATERIALS AND METHODS: A population-based study with a ten-year follow-up. The reference population was formed by 763 individuals aged over 64 years, with no diagnoses of heart or kidney diseases | ||
| 520 | |a RESULTS: There was a significant increase in cTnT and proBNP concentrations with age. The 99 % reference limits for cTnT were 25 ng/L, 28 ng/l, 38 ng/l, and 71 ng/l for men in five-year-intervals starting from 64 to 69 years to 80 years and older, and 18 ng/L, 22 ng/l, 26 ng/l, and 52 ng/L for women, respectively. The 97.5 % reference limits for proBNP were 272 ng/L, 287 ng/l, 373 ng/l and 686 ng/L for men, and 341 ng/L, 377 ng/l, 471 ng/l, and 794 ng/L for women, respectively. Elevated proBNP was statistically significantly associated with future AMIs in subjects with and without a previous heart disease | ||
| 520 | |a CONCLUSIONS: Age-specific reference limits for cTnT and proBNP are needed to better evaluate cardiac symptoms | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cardiac biomarkers | |
| 650 | 4 | |a Elderly | |
| 650 | 4 | |a Myocardial infarction | |
| 650 | 4 | |a Natriuretic peptide | |
| 650 | 4 | |a Reference limits | |
| 650 | 4 | |a Troponin | |
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| 650 | 7 | |a Biomarkers |2 NLM | |
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| 650 | 7 | |a Natriuretic Peptide, Brain |2 NLM | |
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| 700 | 1 | |a Katajamäki, Taina |e verfasserin |4 aut | |
| 700 | 1 | |a Salminen, Marika |e verfasserin |4 aut | |
| 700 | 1 | |a Irjala, Kerttu |e verfasserin |4 aut | |
| 700 | 1 | |a Viljanen, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Koivula, Marja-Kaisa |e verfasserin |4 aut | |
| 700 | 1 | |a Pulkki, Kari |e verfasserin |4 aut | |
| 700 | 1 | |a Isoaho, Raimo |e verfasserin |4 aut | |
| 700 | 1 | |a Kivelä, Sirkka-Liisa |e verfasserin |4 aut | |
| 700 | 1 | |a Viitanen, Matti |e verfasserin |4 aut | |
| 700 | 1 | |a Löppönen, Minna |e verfasserin |4 aut | |
| 700 | 1 | |a Vahlberg, Tero |e verfasserin |4 aut | |
| 700 | 1 | |a Viikari, Laura |e verfasserin |4 aut | |
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