What happens when left meets right under equimolar and non-equimolar co-assembly of short peptide stereoisomers?
Copyright © 2024 Elsevier Inc. All rights reserved..
The co-assembly of different peptide chains usually leads to the formation of intricate architectures and sophisticated functions in biological systems. Although the co-assembly of stereoisomeric peptides represents a facile and flexible strategy for the synthesis of peptide-based nanomaterials with novel structures and potentially interesting properties, there is a lack of a general knowledge on how different isomers pack during assembly. Through the combined use of simulations and experimental observations, we report that heterochiral pairing is preferred to homochiral pairing at the molecular scale but self-sorting dictates beyond the molecular level for the mixtures of the short stereoisomeric β-sheet peptides I3K (Ile-Ile-Ile-Lys). Furthermore, we demonstrate that flat β-sheets and fibril morphology are always preferred to twisted ones during heterochiral pairing and subsequent assembly. However, the heterochiral pairing into flat morphology is not always at an equimolar ratio. Instead, a non-equimolar ratio (1:2) is observed for the mixing of homochiral LI3LK and heterochiral LI3DK, whose strand twisting degrees differ greatly. Such a study provides a paradigm for understanding the co-assembly of stereoisomeric peptides at the molecular scale and harnessing their blending for targeted nanostructures.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:663 |
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| Enthalten in: |
Journal of colloid and interface science - 663(2024) vom: 30. März, Seite 287-294 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Yan [VerfasserIn] |
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| Links: |
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| Themen: |
Co-assembly |
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| Anmerkungen: |
Date Completed 22.03.2024 Date Revised 22.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jcis.2024.02.140 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2024 Elsevier Inc. All rights reserved. | ||
| 520 | |a The co-assembly of different peptide chains usually leads to the formation of intricate architectures and sophisticated functions in biological systems. Although the co-assembly of stereoisomeric peptides represents a facile and flexible strategy for the synthesis of peptide-based nanomaterials with novel structures and potentially interesting properties, there is a lack of a general knowledge on how different isomers pack during assembly. Through the combined use of simulations and experimental observations, we report that heterochiral pairing is preferred to homochiral pairing at the molecular scale but self-sorting dictates beyond the molecular level for the mixtures of the short stereoisomeric β-sheet peptides I3K (Ile-Ile-Ile-Lys). Furthermore, we demonstrate that flat β-sheets and fibril morphology are always preferred to twisted ones during heterochiral pairing and subsequent assembly. However, the heterochiral pairing into flat morphology is not always at an equimolar ratio. Instead, a non-equimolar ratio (1:2) is observed for the mixing of homochiral LI3LK and heterochiral LI3DK, whose strand twisting degrees differ greatly. Such a study provides a paradigm for understanding the co-assembly of stereoisomeric peptides at the molecular scale and harnessing their blending for targeted nanostructures | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Co-assembly | |
| 650 | 4 | |a Flat morphology | |
| 650 | 4 | |a Heterochiral pairing | |
| 650 | 4 | |a Mixing ratio | |
| 650 | 4 | |a Peptide stereoisomers | |
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| 700 | 1 | |a Qi, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Xiaofang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Wenliang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yurong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Muhan |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Xuzhi |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jiqian |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Jian Ren |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Hai |e verfasserin |4 aut | |
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