Bibenzyl and naphthalene derivatives from Dendrobium chrysanthum and their anti-hepatic-steatosis activities
Copyright © 2024. Published by Elsevier Inc..
In this study, 16 new compounds, six bibenzyls (1-6) and 10 naphthalenes (7-13), including three pairs of naphthalene enantiomers and three known compounds (14-16), were isolated from Dendrobium chrysanthum. Structurally, compounds 1-5 are previously undescribed dimeric bibenzyls, uniquely linked by unusual carbon bonds. The structures of the compounds were determined using spectroscopy and X-ray crystallography. The screening results indicated that 1, 2, and 5 showed remarkable lipid-lowering activities in FFA-induced HepG2 cells, with EC50 values ranging from 3.13 to 6.57 μM. Moreover, 1, 2, and 5 significantly decreased both the mRNA and protein levels of the target SREBP-1c, and 5 also reduced PPARα mRNA and protein levels. Therefore, 1, 2, and 5 are potential drugs against hepatic steatosis by targeting PPARα or SREBP-1c.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:145 |
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| Enthalten in: |
Bioorganic chemistry - 145(2024) vom: 15. März, Seite 107236 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Zi-Mo [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-hepatic-steatosis |
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| Anmerkungen: |
Date Completed 15.03.2024 Date Revised 19.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bioorg.2024.107236 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM368927717 |
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| 520 | |a Copyright © 2024. Published by Elsevier Inc. | ||
| 520 | |a In this study, 16 new compounds, six bibenzyls (1-6) and 10 naphthalenes (7-13), including three pairs of naphthalene enantiomers and three known compounds (14-16), were isolated from Dendrobium chrysanthum. Structurally, compounds 1-5 are previously undescribed dimeric bibenzyls, uniquely linked by unusual carbon bonds. The structures of the compounds were determined using spectroscopy and X-ray crystallography. The screening results indicated that 1, 2, and 5 showed remarkable lipid-lowering activities in FFA-induced HepG2 cells, with EC50 values ranging from 3.13 to 6.57 μM. Moreover, 1, 2, and 5 significantly decreased both the mRNA and protein levels of the target SREBP-1c, and 5 also reduced PPARα mRNA and protein levels. Therefore, 1, 2, and 5 are potential drugs against hepatic steatosis by targeting PPARα or SREBP-1c | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anti-hepatic-steatosis | |
| 650 | 4 | |a Dendrobium chrysanthum | |
| 650 | 4 | |a Dimeric bibenzyls | |
| 650 | 4 | |a Naphthalene derivatives | |
| 650 | 7 | |a Bibenzyls |2 NLM | |
| 650 | 7 | |a PPAR alpha |2 NLM | |
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| 700 | 1 | |a Chen, Jin-Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiao-Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ling-Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Shuai |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ya-Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhuang, Peng-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Lu-Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Hang |e verfasserin |4 aut | |
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