Association of Obstructive Sleep Apnea with Post-Acute Sequelae of SARS-CoV-2 Infection
Copyright © 2024 Elsevier Inc. All rights reserved..
BACKGROUND: Obstructive sleep apnea is associated with COVID-19 infection. Less clear is whether obstructive sleep apnea is a risk factor for the development of post-acute sequelae of SARS-CoV-2 infection (PASC).
STUDY DESIGN: Cross-sectional survey of a general population of 24,803 US adults to determine the association of obstructive sleep apnea with PASC.
RESULTS: COVID-19 infection occurred in 10,324 (41.6%) participants. Prevalence of persistent (>3 months post infection) putative PASC-related physical and mental health symptoms ranged from 6.5% (peripheral edema) to 19.6% (nervous/anxious). In logistic regression models, obstructive sleep apnea was associated with all putative PASC-related symptoms with the highest adjusted odds ratios being fever (2.053) and nervous/anxious (1.939). In 4 logistic regression models of overall PASC derived from elastic net regression, obstructive sleep apnea was associated with PASC (range of adjusted odds ratios: 1.934-2.071); this association was mitigated in those with treated obstructive sleep apnea. In the best fitting overall model requiring ≥3 symptoms, PASC prevalence was 21.9%.
CONCLUSION: In a general population sample, obstructive sleep apnea is associated with the development of PASC-related symptoms and a global definition of PASC. Treated obstructive sleep apnea mitigates the latter risk. The presence of 3 or more PASC symptoms may be useful in identifying cases and for future research.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
The American journal of medicine - (2024) vom: 22. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Quan, Stuart F [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Revised 23.03.2024 published: Print-Electronic UpdateOf: medRxiv. 2023 Dec 31;:. - PMID 38234859 Citation Status Publisher |
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| doi: |
10.1016/j.amjmed.2024.02.023 |
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| funding: |
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| PPN (Katalog-ID): |
NLM368916529 |
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| 100 | 1 | |a Quan, Stuart F |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association of Obstructive Sleep Apnea with Post-Acute Sequelae of SARS-CoV-2 Infection |
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| 500 | |a Date Revised 23.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a UpdateOf: medRxiv. 2023 Dec 31;:. - PMID 38234859 | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Obstructive sleep apnea is associated with COVID-19 infection. Less clear is whether obstructive sleep apnea is a risk factor for the development of post-acute sequelae of SARS-CoV-2 infection (PASC) | ||
| 520 | |a STUDY DESIGN: Cross-sectional survey of a general population of 24,803 US adults to determine the association of obstructive sleep apnea with PASC | ||
| 520 | |a RESULTS: COVID-19 infection occurred in 10,324 (41.6%) participants. Prevalence of persistent (>3 months post infection) putative PASC-related physical and mental health symptoms ranged from 6.5% (peripheral edema) to 19.6% (nervous/anxious). In logistic regression models, obstructive sleep apnea was associated with all putative PASC-related symptoms with the highest adjusted odds ratios being fever (2.053) and nervous/anxious (1.939). In 4 logistic regression models of overall PASC derived from elastic net regression, obstructive sleep apnea was associated with PASC (range of adjusted odds ratios: 1.934-2.071); this association was mitigated in those with treated obstructive sleep apnea. In the best fitting overall model requiring ≥3 symptoms, PASC prevalence was 21.9% | ||
| 520 | |a CONCLUSION: In a general population sample, obstructive sleep apnea is associated with the development of PASC-related symptoms and a global definition of PASC. Treated obstructive sleep apnea mitigates the latter risk. The presence of 3 or more PASC symptoms may be useful in identifying cases and for future research | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Long COVID | |
| 650 | 4 | |a Obstructive sleep apnea | |
| 650 | 4 | |a PASC | |
| 650 | 4 | |a Post-acute sequelae of SARS-CoV-2 infection | |
| 700 | 1 | |a Weaver, Matthew D |e verfasserin |4 aut | |
| 700 | 1 | |a Czeisler, Mark É |e verfasserin |4 aut | |
| 700 | 1 | |a Barger, Laura K |e verfasserin |4 aut | |
| 700 | 1 | |a Booker, Lauren A |e verfasserin |4 aut | |
| 700 | 1 | |a Howard, Mark E |e verfasserin |4 aut | |
| 700 | 1 | |a Jackson, Melinda L |e verfasserin |4 aut | |
| 700 | 1 | |a Lane, Rashon I |e verfasserin |4 aut | |
| 700 | 1 | |a McDonald, Christine F |e verfasserin |4 aut | |
| 700 | 1 | |a Ridgers, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Robbins, Rebecca |e verfasserin |4 aut | |
| 700 | 1 | |a Varma, Prerna |e verfasserin |4 aut | |
| 700 | 1 | |a Wiley, Joshua F |e verfasserin |4 aut | |
| 700 | 1 | |a Rajaratnam, Shantha M W |e verfasserin |4 aut | |
| 700 | 1 | |a Czeisler, Charles A |e verfasserin |4 aut | |
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