Overexpression of MTMR14 induced learning and memory impairments in 2-month-old C57 mice
Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved..
Multiple biological functions of MTMR14 including regulation of autophagy, inflammation and Ca2+ homeostasis have been reported. However, its functional contribution to learning and memory remains unclear. In this study, we investigated whether upregulation of MTMR14 induced cognitive impairment and the underlying mechanisms. MTMR14 level was significantly increased in cells or brain tissues that overexpressed P301S-tau. The fusion of autophagosome and lysosome was significantly inhibited by overexpression of MTMR14 or P301S-tau. Upregulation of MTMR14 led to cognitive impairments in 2-month-old mice by inhibiting synaptic protein expression. These findings suggest that MTMR14 may be a key risk factor for cognitive ability.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:825 |
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| Enthalten in: |
Neuroscience letters - 825(2024) vom: 10. März, Seite 137700 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Feng, Qiong [VerfasserIn] |
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| Links: |
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| Themen: |
Alzheimer’s diseases |
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| Anmerkungen: |
Date Completed 18.03.2024 Date Revised 18.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neulet.2024.137700 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM368916162 |
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| 245 | 1 | 0 | |a Overexpression of MTMR14 induced learning and memory impairments in 2-month-old C57 mice |
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| 520 | |a Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Multiple biological functions of MTMR14 including regulation of autophagy, inflammation and Ca2+ homeostasis have been reported. However, its functional contribution to learning and memory remains unclear. In this study, we investigated whether upregulation of MTMR14 induced cognitive impairment and the underlying mechanisms. MTMR14 level was significantly increased in cells or brain tissues that overexpressed P301S-tau. The fusion of autophagosome and lysosome was significantly inhibited by overexpression of MTMR14 or P301S-tau. Upregulation of MTMR14 led to cognitive impairments in 2-month-old mice by inhibiting synaptic protein expression. These findings suggest that MTMR14 may be a key risk factor for cognitive ability | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alzheimer’s diseases | |
| 650 | 4 | |a Autophagy | |
| 650 | 4 | |a Learning and memory | |
| 650 | 4 | |a MTMR14 | |
| 650 | 4 | |a P301S | |
| 650 | 4 | |a Synapse | |
| 650 | 7 | |a tau Proteins |2 NLM | |
| 650 | 7 | |a MTMR14 protein, mouse |2 NLM | |
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| 650 | 7 | |a Phosphoric Monoester Hydrolases |2 NLM | |
| 650 | 7 | |a EC 3.1.3.2 |2 NLM | |
| 700 | 1 | |a Li, Xiao |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ruijuan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Gongping |e verfasserin |4 aut | |
| 700 | 1 | |a He, Ye |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ting |e verfasserin |4 aut | |
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