Multiomics insights into the female reproductive aging
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved..
The human female reproductive lifespan significantly diminishes with age, leading to decreased fertility, reduced fertility quality and endocrine function disorders. While many aspects of aging in general have been extensively documented, the precise mechanisms governing programmed aging in the female reproductive system remain elusive. Recent advancements in omics technologies and computational capabilities have facilitated the emergence of multiomics deep phenotyping. Through the application and refinement of various high-throughput omics methods, a substantial volume of omics data has been generated, deepening our comprehension of the pathogenesis and molecular underpinnings of reproductive aging. This review highlights current and emerging multiomics approaches for investigating female reproductive aging, encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics. We elucidate their influence on fundamental cell biology and translational research in the context of reproductive aging, address the limitations and current challenges associated with multiomics studies, and offer a glimpse into future prospects.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:95 |
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| Enthalten in: |
Ageing research reviews - 95(2024) vom: 15. März, Seite 102245 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wei, Simin [VerfasserIn] |
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| Links: |
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| Themen: |
Female reproductive aging |
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| Anmerkungen: |
Date Completed 12.03.2024 Date Revised 12.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.arr.2024.102245 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a The human female reproductive lifespan significantly diminishes with age, leading to decreased fertility, reduced fertility quality and endocrine function disorders. While many aspects of aging in general have been extensively documented, the precise mechanisms governing programmed aging in the female reproductive system remain elusive. Recent advancements in omics technologies and computational capabilities have facilitated the emergence of multiomics deep phenotyping. Through the application and refinement of various high-throughput omics methods, a substantial volume of omics data has been generated, deepening our comprehension of the pathogenesis and molecular underpinnings of reproductive aging. This review highlights current and emerging multiomics approaches for investigating female reproductive aging, encompassing genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics. We elucidate their influence on fundamental cell biology and translational research in the context of reproductive aging, address the limitations and current challenges associated with multiomics studies, and offer a glimpse into future prospects | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Female reproductive aging | |
| 650 | 4 | |a Fertility | |
| 650 | 4 | |a Hypothalamus-pituitary axis | |
| 650 | 4 | |a Multiomics | |
| 650 | 4 | |a Ovary | |
| 650 | 4 | |a Uterine | |
| 700 | 1 | |a Tang, Weicheng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Xiong, Jiaqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Xue, Liru |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Yican |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Chuqing |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Shixuan |e verfasserin |4 aut | |
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