Bakuchiol nanoemulsion loaded electrospun nanofibers for the treatment of burn wounds
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
The present work aims to develop and evaluate the wound healing potential of bakuchiol nanoemulsion loaded electrospun scaffolds. Since oxidative stress and microbial burden leads the burn wounds to become chronic and fatal to patients, a phytoconstituent, bakuchiol (BAK), was screened on the basis of antioxidant and antimicrobial potential which also defined its dose. Furthermore, BAK was incorporated into a nanoemulsion to enhance its therapeutic efficacy, reduce its dosage frequency, and maximize its stability. The present study is inclined towards the collaborative interaction of natural products and novel drug delivery systems to develop safe and therapeutically efficient systems for burn wound healing. The optimized nanoemulsion showed excellent antioxidant and antimicrobial potential against wound susceptible pathogens, i.e., Candida albicans and Methicillin-resistant Staphylococcus aureus which was further loaded into gelatin based hydrogel and nanofibrous scaffold system. The mesh structure of scaffolds was chosen as a suitable carrier system for wound healing process not only because it offers resemblance to skin's anatomy but is also capable of providing uniform distribution of wound biomarkers across the skin. The prepared nanofibers were assessed for their analgesic, anti-inflammatory, and wound healing potential which was observed to be significantly better than its gel formulation.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Naunyn-Schmiedeberg's archives of pharmacology - (2024) vom: 24. Feb. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kaur, Kirandeep [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Anti-microbial |
|---|
| Anmerkungen: |
Date Revised 24.02.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1007/s00210-024-03011-z |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM368908747 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM368908747 | ||
| 003 | DE-627 | ||
| 005 | 20240229151926.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240229s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00210-024-03011-z |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1305.xml |
| 035 | |a (DE-627)NLM368908747 | ||
| 035 | |a (NLM)38400898 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kaur, Kirandeep |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Bakuchiol nanoemulsion loaded electrospun nanofibers for the treatment of burn wounds |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 24.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a The present work aims to develop and evaluate the wound healing potential of bakuchiol nanoemulsion loaded electrospun scaffolds. Since oxidative stress and microbial burden leads the burn wounds to become chronic and fatal to patients, a phytoconstituent, bakuchiol (BAK), was screened on the basis of antioxidant and antimicrobial potential which also defined its dose. Furthermore, BAK was incorporated into a nanoemulsion to enhance its therapeutic efficacy, reduce its dosage frequency, and maximize its stability. The present study is inclined towards the collaborative interaction of natural products and novel drug delivery systems to develop safe and therapeutically efficient systems for burn wound healing. The optimized nanoemulsion showed excellent antioxidant and antimicrobial potential against wound susceptible pathogens, i.e., Candida albicans and Methicillin-resistant Staphylococcus aureus which was further loaded into gelatin based hydrogel and nanofibrous scaffold system. The mesh structure of scaffolds was chosen as a suitable carrier system for wound healing process not only because it offers resemblance to skin's anatomy but is also capable of providing uniform distribution of wound biomarkers across the skin. The prepared nanofibers were assessed for their analgesic, anti-inflammatory, and wound healing potential which was observed to be significantly better than its gel formulation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anti-microbial | |
| 650 | 4 | |a Bakuchiol | |
| 650 | 4 | |a Nanoemulsion | |
| 650 | 4 | |a Nanofibers | |
| 650 | 4 | |a Wound-healing | |
| 700 | 1 | |a Kant, Shubham |e verfasserin |4 aut | |
| 700 | 1 | |a Chaudary, Tajeshwar Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Mehra, Anshula |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Atamjit |e verfasserin |4 aut | |
| 700 | 1 | |a Attri, Shivani |e verfasserin |4 aut | |
| 700 | 1 | |a Gasso, Sahil |e verfasserin |4 aut | |
| 700 | 1 | |a Mahajan, Aman |e verfasserin |4 aut | |
| 700 | 1 | |a Bedi, Neena |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Naunyn-Schmiedeberg's archives of pharmacology |d 1972 |g (2024) vom: 24. Feb. |w (DE-627)NLM000008354 |x 1432-1912 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:24 |g month:02 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00210-024-03011-z |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 24 |c 02 | ||