Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation
OBJECTIVE: Breast cancer is a global health concern that demands attention. In our contribution to addressing this disease, our study focuses on investigating a wireless micro-device for intratumoral drug delivery, utilizing electrochemical actuation. Microdevices have emerged as a promising approach in this field due to their ability to enable controlled injections in various applications.
METHODS: Our study is conducted within a computational framework, employing models that simulate the behavior of the microdevice and drug discharge based on the principles of the ideal gas law. Furthermore, the distribution of the drug within the tissue is simulated, considering both diffusion and convection mechanisms. To predict the therapeutic response, a pharmacodynamic model is utilized, considering the chemotherapeutic effects and cell proliferation.
RESULTS: The findings demonstrate that an effective current of 3 mA, along with an initial gas volume equal to the drug volume in the microdevice, optimizes drug delivery. Microdevices with multiple injection capabilities exhibit enhanced therapeutic efficacy, effectively suppressing cell proliferation. Additionally, tumors with lower microvascular density experience higher drug concentrations in the extracellular space, resulting in significant cell death in hypoxic regions.
CONCLUSIONS: Achieving an efficient therapeutic response involves considering both the characteristics of the tumor microenvironment and the frequency of injections within a specific time frame.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Expert opinion on drug delivery - (2024) vom: 28. Feb., Seite 1-17 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Souri, Mohammad [VerfasserIn] |
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| Links: |
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| Themen: |
Breast cancer |
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| Anmerkungen: |
Date Revised 28.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1080/17425247.2024.2323211 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM36886345X |
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| 245 | 1 | 0 | |a Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation |
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| 500 | |a Date Revised 28.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a OBJECTIVE: Breast cancer is a global health concern that demands attention. In our contribution to addressing this disease, our study focuses on investigating a wireless micro-device for intratumoral drug delivery, utilizing electrochemical actuation. Microdevices have emerged as a promising approach in this field due to their ability to enable controlled injections in various applications | ||
| 520 | |a METHODS: Our study is conducted within a computational framework, employing models that simulate the behavior of the microdevice and drug discharge based on the principles of the ideal gas law. Furthermore, the distribution of the drug within the tissue is simulated, considering both diffusion and convection mechanisms. To predict the therapeutic response, a pharmacodynamic model is utilized, considering the chemotherapeutic effects and cell proliferation | ||
| 520 | |a RESULTS: The findings demonstrate that an effective current of 3 mA, along with an initial gas volume equal to the drug volume in the microdevice, optimizes drug delivery. Microdevices with multiple injection capabilities exhibit enhanced therapeutic efficacy, effectively suppressing cell proliferation. Additionally, tumors with lower microvascular density experience higher drug concentrations in the extracellular space, resulting in significant cell death in hypoxic regions | ||
| 520 | |a CONCLUSIONS: Achieving an efficient therapeutic response involves considering both the characteristics of the tumor microenvironment and the frequency of injections within a specific time frame | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Drug delivery | |
| 650 | 4 | |a breast cancer | |
| 650 | 4 | |a electrochemical actuation | |
| 650 | 4 | |a mathematical modeling | |
| 650 | 4 | |a wireless bioelectronic | |
| 700 | 1 | |a Elahi, Sohail |e verfasserin |4 aut | |
| 700 | 1 | |a Soltani, Madjid |e verfasserin |4 aut | |
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