Threats of per- and poly-fluoroalkyl pollutants to susceptible populations
Copyright © 2024. Published by Elsevier B.V..
Environmental exposure to per- and poly-fluoroalkyl substances (PFAS) has raised significant global health concerns due to potential hazards in healthy adults. However, the impact of PFAS on susceptible populations, including pregnant individuals, newborns, the older people, and those with underlying health conditions, has been overlooked. These susceptible groups often have physiological changes that make them less resilient to the same exposures. Consequently, there is an urgent need for a comprehensive understanding of the health risks posed by PFAS exposure to these populations. In this review, we delve into the potential health risks of PFAS exposure in these susceptible populations. Equally important, we also examine and discuss the molecular mechanisms that underlie this susceptibility. These mechanisms include the induction of oxidative stress, disruption of the immune system, impairment of cellular metabolism, and alterations in gut microbiota, all of which contribute to the enhanced toxicity of PFAS in susceptible populations. Finally, we address the primary research challenges and unresolved issues that require further investigation. This discussion aims to foster research for a better understanding of how PFAS affect susceptible populations and to pave the way for strategies to minimize their adverse effects.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:921 |
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| Enthalten in: |
The Science of the total environment - 921(2024) vom: 15. März, Seite 171188 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mao, Xuan [VerfasserIn] |
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| Links: |
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| Themen: |
Alkanesulfonic Acids |
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| Anmerkungen: |
Date Completed 11.03.2024 Date Revised 11.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.scitotenv.2024.171188 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2024. Published by Elsevier B.V. | ||
| 520 | |a Environmental exposure to per- and poly-fluoroalkyl substances (PFAS) has raised significant global health concerns due to potential hazards in healthy adults. However, the impact of PFAS on susceptible populations, including pregnant individuals, newborns, the older people, and those with underlying health conditions, has been overlooked. These susceptible groups often have physiological changes that make them less resilient to the same exposures. Consequently, there is an urgent need for a comprehensive understanding of the health risks posed by PFAS exposure to these populations. In this review, we delve into the potential health risks of PFAS exposure in these susceptible populations. Equally important, we also examine and discuss the molecular mechanisms that underlie this susceptibility. These mechanisms include the induction of oxidative stress, disruption of the immune system, impairment of cellular metabolism, and alterations in gut microbiota, all of which contribute to the enhanced toxicity of PFAS in susceptible populations. Finally, we address the primary research challenges and unresolved issues that require further investigation. This discussion aims to foster research for a better understanding of how PFAS affect susceptible populations and to pave the way for strategies to minimize their adverse effects | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Disease | |
| 650 | 4 | |a Health risks | |
| 650 | 4 | |a PFAS | |
| 650 | 4 | |a Physiological states | |
| 650 | 4 | |a Susceptible populations | |
| 650 | 7 | |a Environmental Pollutants |2 NLM | |
| 650 | 7 | |a Fluorocarbons |2 NLM | |
| 650 | 7 | |a Alkanesulfonic Acids |2 NLM | |
| 700 | 1 | |a Liu, Yujiao |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Yongyi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiaodi |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yin |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Gaoxing |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaohong |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Jianbo |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Bing |e verfasserin |4 aut | |
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